| 程若川.分化型甲状腺癌术后促甲状腺激素抑制治疗分析[J].中国肿瘤,2015,24(6):456-460. |
| 分化型甲状腺癌术后促甲状腺激素抑制治疗分析 |
| An Analysis of Postoperative Thyrotropin Suppression for Differentiated Thyroid Carcinoma |
| 投稿时间：2015-01-06 |
| DOI：10.11735/j.issn.1004-0242.2015.06.A005 |
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| 中文关键词: 分化型甲状腺癌 促甲状腺激素 抑制治疗 |
| 英文关键词:differentiated thyroid cancer thyrotropin suppressive therapy |
| 基金项目: |
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| 中文摘要: |
| 摘 要：目前对于分化型甲状腺癌的治疗方法通常为手术治疗合并放射碘治疗以及甲状腺激素替代治疗，并且根据疾病的不同分期，患者的促甲状腺激素（thyrotropin，TSH）应维持在低于正常或极低水平。目前对于TSH抑制治疗的争议主要存在于最佳抑制程度，即是否应将TSH抑制到<0.1 mU/L还是保持在0.1～0.4 mU/L以达到最佳疗效，以及在不同分期患者中，TSH抑制治疗的有效性。全文对TSH抑制治疗对甲状腺癌的应用进行分析，并对TSH抑制治疗的利弊、抑制程度进行讨论，以及目前存在的关于TSH抑制治疗的争议进行阐述。 |
| 英文摘要: |
| Abstract：The treatmont for differentiated thyroid cancer(DTC) usually consists of a combination of surgery，radioactive iodine (RAI) therapy and thyroid hormone replacement aimed at maintaining based on the different stages of the disease，thyroid-stimulating hormone/thyrotropin (TSH) levels should keep at a very low or less than normal range. Up to date，the main argument against TSH suppression is the extent of serum TSH concentration required for optimal treatment，namely whether to suppress TSH below 0.1mU/L or to maintain TSH between 0.1～0.4mU/L，and the efficiency of TSH suppression in patients with different disease stages. Some key issues in TSH-suppression therapy are discussed in this essay，including a brief review of TSH suppression for thyroid cancer，both benefits and risks of TSH suppression and the extent of suppression. Finally，current controversies in TSH suppression therapy will be illustrated. |
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