| 王少明,范金虎,张雨晴.甲状腺肿可能增加胃癌的死亡风险——林县营养干预试验27年随访结果[J].中国肿瘤,2015,24(6):439-443. |
| 甲状腺肿可能增加胃癌的死亡风险——林县营养干预试验27年随访结果 |
| Goiter is Probably Associated with Increased Risk of Gastric Cancer，A Study with 27-years Follow-up in a Large Population-based Chinese Cohort |
| 投稿时间：2015-01-23 |
| DOI：10.11735/j.issn.1004-0242.2015.06.A001 |
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| 中文关键词: 胃癌 甲状腺肿 碘缺乏 队列研究 |
| 英文关键词:gastric cancer goiter iodine deficiency cohort study |
| 基金项目: |
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| 摘要点击次数: 2287 |
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| 中文摘要: |
| 摘 要：［目的］ 通过队列研究探讨甲状腺肿患者胃癌的死亡风险。［方法］ 1985年选取林县年龄为40~69岁的研究对象29 584名，开展基线人口特征、生活习惯、疾病史等调查后，进行为期5.25年的营养干预试验，对该人群随访至今约27年。以胃癌死亡病例作为研究终点，通过Cox比例风险模型计算基线甲状腺肿病史对胃癌死亡风险的长期影响。［结果］ 年龄、男性、吸烟和甲状腺肿病史均可增加胃癌的长期死亡风险，适量饮酒可降低胃癌的死亡风险。基线自我报告曾被诊断为甲状腺肿病的人群胃癌死亡风险显著增高（HR=1.45，95%CI：1.01~2.10，P=0.046）。［结论］ 甲状腺肿病史可能增加胃癌的长期死亡风险，其详细病因学机制有待进一步探讨。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the long-term risk of death from gastric cancer for goiter. ［Methods］ In 1985，a population of 29 584 aged 40～69 years were enrolled into the Nutrition Intervention Trial in Linxian，China. Demographics information，lifestyle，and disease histories were surveyed at baseline and the nutrition intervention lasted for 5.25 years. Monthly follow-up were conducted thereafter to collect cancer incidence and deaths for more than 27 years. Using deaths of gastric cancer as endpoints，Cox proportional hazards models were used to calculate hazard ratios(HRs) and 95% confidence intervals (95%CIs) for goiter. ［Results］ Age，male，smoking and a history of goiter significantly increased the risk of deaths from gastric cancer，but appropriate drinking reduced the risk of gastric cancer. A self-reported history of physician-diagnosed goiter at baseline was associated with a significantly increased risk of gastric cancer in 27 years (HR=1.45，95%CI：1.01～2.10，P=0.046). ［Conclusion］ Goiter is probably associated with an increased risk of gastric cancer，but the etiological mechanism needs to be further investigated. |
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