| 沈 迪,王小兵,车轶群.血清巨噬细胞抑制因子-1在肺癌诊断中的临床应用[J].中国肿瘤,2015,24(5):421-425. |
| 血清巨噬细胞抑制因子-1在肺癌诊断中的临床应用 |
| Clinical Application of Serum Macrophage Inhibitory Cytokine-1 for Diagnosis of Lung Cancer |
| 投稿时间：2014-12-29 |
| DOI：10.11735/j.issn.1004-0242.2015.05.A015 |
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| 中文关键词: 巨噬细胞抑制因子-1 肿瘤标志物 肺癌 诊断 |
| 英文关键词:macrophages inhibitory cytokine-1 tumor marker lung cancer diagnosis |
| 基金项目:国家高技术研究发展863计划资助项目（2008AA02Z415）； |
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| 中文摘要: |
| 摘 要：［目的］ 研究巨噬细胞抑制因子-1(MIC-1) 血清水平在肺癌诊断中的临床应用价值。［方法］ 采用ELISA方法检测324例肺癌患者、48例肺良性疾病患者和229例正常对照人群血清MIC-1浓度，并检测肺癌患者血清CEA、CA125、NSE、CYFRA21-1和SCC浓度。［结果］ 肺癌组患者血清中MIC-1浓度显著性高于正常对照组（P<0.001）和肺良性疾病组(P<0.001)。 MIC-1诊断肺癌的敏感度和特异性分别为71.3%和96.5%。MIC-1诊断肺癌的敏感度优于已有标志物CEA、CA125、NSE、SCC和CYFRA21-1；在肺癌早期（Ⅰ~Ⅱ期）阶段，MIC-1的敏感度优于其他5种标志物的联合诊断（Ⅰ期：66.7% vs 47.6%，Ⅱ期：71.7% vs 65.0%）；6种标志物联合诊断则能使Ⅰ期和Ⅱ期肺癌诊断敏感度分别提高至77.1%和83.3%。［结论］ MIC-1可能成为比较理想的肺癌诊断标志物。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinical value of macrophage inhibitory cytokine-1 (MIC-1) as a serum tumor marker for the diagnosis of lung cancer. ［Methods］ The double antibody sandwich ELISA was used to detect serum MIC-1 level in 324 cases with lung cancer，48 cases with benign pulmonary disease and 229 healthy persons. Serum CEA，CA125，NSE，CYFRA21-1and SCC levels were also detected.［Results］ MIC-1 concentration in lung cancer group was significantly higher than that in healthy persons group (P<0.001）and in benign disease group (P<0.001). The specificity and sensitivity of MIC-1 for lung cancer were 96.5% and 71.3% respectively. The sensitivity of MIC-1 for early stage of lung cancer was higher than that of CEA，CA125，NSE，SCC and CYFRA21-1 respectively. The sensitivity of MIC-1 for early stage of lung cancer (stage Ⅰ and stage Ⅱ) was higher than the combination of the above five markers（stage Ⅰ：66.7% vs 47.6%；stage Ⅱ：71.7% vs 65.0%）. The sensitivity for stage Ⅰ and stage Ⅱ reached 77.1% and 83.3% respectively in the combination of the six markers. ［Conclusions］ Serum MIC-1 level might be an ideal marker in diagnosis for lung cancer. |
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