雷泽民,余宗阳.非小细胞肺癌T细胞PD-1免疫靶向治疗研究现状与展望[J].中国肿瘤,2015,24(5):398-402. |
非小细胞肺癌T细胞PD-1免疫靶向治疗研究现状与展望 |
Research Situation and Prospect of PD-1-targeted Immune-Targeted Treatment for NSCLC |
投稿时间:2014-08-06 |
DOI:10.11735/j.issn.1004-0242.2015.05.A011 |
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中文关键词: 非小细胞肺癌 免疫治疗 靶向治疗 PD-1 |
英文关键词:non-small cell lung cancer immunotherapy targeted therapy PD-1 |
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中文摘要: |
摘 要:程序性细胞死亡1 (programmed death 1,PD-1),是一种主要表达于肿瘤患者活化T细胞上的抑制性受体。在肿瘤患者中,通过PD-1高表达,介导T细胞免疫负性调控信号,参与肿瘤免疫反应的负调节。近年来,以PD-1为靶点的免疫靶向治疗成为肿瘤免疫治疗新兴热点,为非小细胞肺癌免疫靶向治疗提供了一个新方向。 |
英文摘要: |
Abstract: Programmed cell death 1 (PD-1) is a major inhibitory receptor expressed on the surface of activated T cells. In cancer patients,PD-1 is commonly over-expressed and participated in modification of downstream signal pathway,negatively regulate immune response. Recently,the PD-1-targeted immune-targeted treatment,becomes a highlight in tumor immunotherapy and provides a new direction for immune targeted therapy for non-small cell lung cancer. |
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