| 喻 靓,张 煜,卢仁泉.Cys C、β2-MG、RBP、MAU在肿瘤患者化疗后早期肾损伤中的临床意义[J].中国肿瘤,2015,24(4):340-343. |
| Cys C、β2-MG、RBP、MAU在肿瘤患者化疗后早期肾损伤中的临床意义 |
| The Diagnostic Significance of Cystatin C，β2-microglobin，Retinol Binding Protein and Microalbuminuria in Detection of Early Renal Damage in Thermotherapy for Patients with Cancer |
| 投稿时间：2014-03-23 |
| DOI：10.11735/j.issn.1004-0242.2015.04.A018 |
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| 中文关键词: 化疗 肾损伤 半胱氨酸蛋白酶抑制剂C β2-微球蛋白 视黄醇结合蛋白 尿微量白蛋白 顺铂 |
| 英文关键词:chemotherapy renal function damage cystatin C β2-microglobin retinol binding protein microalbuminuria cisplatin |
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| 中文摘要: |
| 摘 要：［目的］ 探讨恶性肿瘤患者化疗后早期肾损伤敏感指标的临床应用。［方法］ 分别检测恶性肿瘤患者化疗前及化疗后血清半胱氨酸蛋白酶抑制剂C(cystatin C，Cys C)、β2-微球蛋白（β2-microglobin，β2-MG）、视黄醇结合蛋白(retinol binding protein，RBP)、肌酐（CRE）、尿素氮（BUN）以及尿微量白蛋白（microalbuminuria，MAU）、尿肌酐(Cr)水平。［结果］ 血Cys C在第2次化疗后明显升高﹙P＜0.05），血β2-MG、RBP、BUN、CRE及MAU/Cr值在患者2次化疗后均无显著变化﹙P>0.05）。第2次化疗后，血Cys C单独检测阳性率为20%，联合血β2-MG检测阳性率为40%。按化疗方案分组，含顺铂（DDP）组血Cys C在第2次化疗后明显升高﹙P＜0.05），而非DDP组2次化疗后均无明显变化﹙P>0.05）。［结论］ 血Cys C在诊断化疗后肾脏早期损伤时优于常规肾功能指标，尤其适用于化疗方案含DDP患者早期肾损伤的监测。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the application of markers of renal function damage in cancer patients after chemotherapy. ［Methods］ Serum level of Cystatin C(Cys C)，β2-microglobin (β2-MG)，retinol binding protein(RBP)，blood Urea (BUN)，Creatinine (CRE) and Microalbuminuria(MAU) were detected in patients with cancer at baseline and several days after chemotherapy respectively. ［Results］ Serum level of Cys C increased significantly after the second cycle of chemotherapy(P<0.05).The levels of β2-MG，RBP，MAU，BUN and CRE had no significant differences after two cycles of chemotherapy(P>0.05). After the second cycle of chemotherapy，the positive rate of Cys C was 20%，but it of combined determination of Cys C and β2-MG was 40%. Grouped by chemotherapy，the level of Cys C increased significantly after the second cycle of chemotherapy in cancer patients received cisplatin(DDP)-containing protocols(P<0.05)，but no significant differences for those receiving non-cisplatin-containing ones(P>0.05). ［Conclusions］ Detecting the levels of Cys C has a higher valuation in early diagnosing renal function damage. Especially，it is appropriate for cancer patients treated with combined chemotherapy with DDP. |
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