| 刘永蕊,刘静蕾,唐国栋.PDCD5基因与非小细胞肺癌的研究进展[J].中国肿瘤,2015,24(4):302-306. |
| PDCD5基因与非小细胞肺癌的研究进展 |
| Research Progress of PDCD5 in Non-small Cell Lung Cancer |
| 投稿时间：2014-09-10 |
| DOI：10.11735/j.issn.1004-0242.2015.04.A011 |
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| 中文关键词: PDCD5 非小细胞肺癌 文献分析 |
| 英文关键词:PDCD5 non-small cell lung cancer literature review |
| 基金项目: |
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| 摘要点击次数: 2499 |
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| 中文摘要: |
| 摘 要：程序性细胞死亡分子5（programmed cell death 5，PDCD5）作为一种重要的凋亡正调控分子，在许多疾病的发生发展过程中起着重要作用。PDCD5在肺癌、结直肠癌、卵巢癌、乳腺癌等多种恶性肿瘤细胞株、患者血清及其肿瘤组织中均有表达水平下降，而在骨关节炎、狼疮性肾炎、支气管哮喘等自身免疫性疾病中表达上调。大量的临床实验研究涉及了PDCD5与非小细胞肺癌之间的关系，全文就目前PDCD5与非小细胞肺癌的研究进展作一综述。 |
| 英文摘要: |
| Abstract：Programmed cell death 5(PDCD5) is an important molecule related to apoptosis and plays important roles in the process of many diseases.PDCD5 was under-expression in a variety of lung cancer，colorectal cancer，ovarian cancer，breast cancer and other malignant tumor cells，serum and tumor tissue. However，PDCD5 was overexpressed in autoimmune disease，such as osteoarthritis，lupus nephritis，bronchial asthma. A large quantity of clinical experiments studies concern the relationship between PDCD5 and non-small cell lung cancer. The current research progress of PDCD5 and non-small cell lung cancer were reviewed in this paper. |
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