| 覃玲艳,王华新,王立波.CD147、EGFR及HIF-1α与肿瘤的侵袭及转移[J].中国肿瘤,2015,24(2):127-133. |
| CD147、EGFR及HIF-1α与肿瘤的侵袭及转移 |
| The Role of CD147，EGFR and HIF-1α in Tumor Invasion and Metastasis |
| 投稿时间：2014-04-20 |
| DOI：10.11735/j.issn.1004-0242.2015.02.A011 |
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| 中文关键词: CD147 EGFR HIF-1α 肿瘤 侵袭 转移 |
| 英文关键词:CD147 EGFR HIF-1α tumor invasion metastasis |
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| 摘要点击次数: 2055 |
| 全文下载次数: 1093 |
| 中文摘要: |
| 摘 要：肿瘤的侵袭和转移是一个长期受多因素影响的演变过程，涉及许多分子表达水平的变化，受肿瘤微环境的影响。肿瘤微环境是肿瘤细胞、细胞外基质、肿瘤相关的血管、淋巴管、各种细胞因子等在肿瘤组织周围形成的对肿瘤细胞生长产生影响的环境。基质金属蛋白酶诱导因子（CD147）、表皮生长因子受体（EGFR）、乏氧诱导因子（HIF-1α）是肿瘤微环境中具有代表性的因子。全文就细胞外CD147、EGFR及HIF-1α在肿瘤的侵袭与转移中的相关作用机制作一综述。 |
| 英文摘要: |
| Abstract：The invasion and metastasis of tumor is a long-term process and is involving many factors， such as molecular expression and the tumor microenvironment etc. Tumor microenvironment is composed of tumor cells，extracellular matrix，tumor blood vessels，lymphatic vessels and all kinds of cytokines. The environment forms around the tumor tissue and impacts on the tumor cell growth. The CD147，EGFR and HIF-1α are the typical factors in tumor microenvironment. In this paper，the CD147，EGFR and HIF-1α related mechanism in tumor invasion and metastasis were reviewed. |
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