| 中文关键词: miR-494 肿瘤 增殖 凋亡 靶基因 |
| 英文关键词:miR-494 tumor proliferation apoptosis target gene |
| 基金项目:深圳市科技研发资金基础研究计划资助项目 |
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| 中文摘要: |
| 摘 要：microRNAs（简称miRNAs）是一种由22个核苷酸组成的内源性非编码小分子单链RNA，成熟的miRNA与靶基因互补序列相结合来调控基因的表达，从而参与细胞的增殖、分化和凋亡。miR-494作为miRNAs家族中的一员，在肝癌、肺癌、胃肠道肿瘤、脑部肿瘤等疾病中呈现不同的差异表达，其通过发挥抑癌基因或癌基因样作用影响肿瘤细胞的增殖、分化、凋亡等生物学过程，从而影响肿瘤的发生发展。全文就miR-494与肿瘤关系的研究进展进行综述。 |
| 英文摘要: |
| Abstract：MicroRNAs(miRNAs) are endogenous non coding small single chain RNAs composed of 22 nucleotides，mature miRNAs regulate the expression of gene by targeting the complementary sequence combination，which are involved in the cell proliferation，differentiation and apoptosis.miR-494，as a member of the miRNAs family，has a great different expression in hepatocellular carcinoma，lung cancer，gastrointestinal cancer，brain tumor and so on，it influences the occurrence and development of the tumor by playing a tumor suppressor or an oncogene to effect the proliferation，differentiation，apoptosis and other biological processes of the tumor cells. The research progresses of miR-494 in tumors were reviewed in this aritcal. |
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