| 郭红云,杨碎胜,张斌明.甘肃汉族女性XPF基因多态性与散发乳腺癌易感性的相关性分析[J].中国肿瘤,2015,24(2):106-109. |
| 甘肃汉族女性XPF基因多态性与散发乳腺癌易感性的相关性分析 |
| The Relationship between Single Nucleotide Polymorphisms of XPF and Susceptibility of Sporadic Breast Cancer of Han Women in Gansu Province |
| 投稿时间：2014-09-04 |
| DOI：10.11735/j.issn.1004-0242.2015.02.A006 |
|
 |
| 中文关键词: XPF 单核苷酸多态性 散发性乳腺癌 汉族 |
| 英文关键词:XPF single nucleotide polymorphisms sporadic breast cancer Han nationality |
| 基金项目:甘肃省卫生行业计划项目，甘肃省科技支撑计划（1011FKCA089） |
|
| 摘要点击次数: 2221 |
| 全文下载次数: 956 |
| 中文摘要: |
| 摘 要：［目的］ 探讨着色性干皮病基因组F（XPF）rs3136189及rs1800067单核苷酸多态性（SNPs）与甘肃汉族妇女散发乳腺癌的关系。［方法］ 采用以自然人群为基础的病例对照设计，对101例乳腺癌和1∶1成组频数匹配原则获得的101例对照进行研究。基因分型采用聚合酶链反应-限制性内切酶片段长度多态性（PCR-RFLP）分析方法，采用非条件Logistic回归模型评估各SNP基因型与乳腺癌发病风险的关联。［结果］ 甘肃汉族妇女人群正常对照组XPF基因SNP位点rs3136189的TT、CT和CC基因频率分别为59.41%、39.60%和0.99%，而乳腺癌组分布频率分别为53.47%、40.59%和5.94%。rs1800067正常对照组的GG、AG和AA基因频率分别为98.02%、1.98%和0，乳腺癌组分别为99.01%、0.99%、0。2个SNPs位点基因型和等位基因在两组间分布差异均无统计学意义（P＞0.05）。乳腺癌患者肿瘤大小、有无淋巴结转移及ER、PR、C-erbB-2、p53和Ki67蛋白表达与rs3136189位点基因型频率分布均无相关性（P＞0.05）。［结论］ 甘肃汉族妇女人群XPF基因 rs3136189及rs1800067多态性位点与乳腺癌的发病风险间未发现显著性关联。 |
| 英文摘要: |
| Abstract：［Purpose］To investigate the relationship of XPF rs3136189 and rs1800067 polymorphisms with the susceptibility of sporadic breast cancer in Gansu woman of Han population. ［Methods］ In this population-based case-control study，101 cases with breast cancer and 101 matched controls in terms of habitation and age(±5 years) were recruited. Genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The odd-ratios(OR) and 95% confidence intervals(CI) were calculated by unconditional logistic regression model. ［Results］ The genotype frequencies of TT，TC and CC of the rs3136189 were 59.41%39.60% and 0.99% in the controls，and in breast cancer cases were 53.47%，40.59% and 5.94% respectively. The genotype frequencies of GG，GA and AA of rs1800067 were 99.01%，0.99% and 0 in the controls，and in breast cancer cases were 99.01%、0.99% and 0 respectively.Compared to the controls，no significant differences were found in the genotype frequencies and allele frequencies(P>0.05). The rs3136189 polymorphisms was not significantly associated with clinicopathologic features，including tumor size，lymph node metastases，ER，PR，CerbB-2，p53 and Ki67(P>0.05). ［Conclusion］ XPF rs3136189 andrs1800067 polymorphisms are not related to the susceptibility of sporadic breast cancer of Han women in Gansu province. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |