| 池苗苗,戴飞飞,王亚坤.Her-2表达在食管胃结合部腺癌中的作用研究进展[J].中国肿瘤,2015,24(1):49-52. |
| Her-2表达在食管胃结合部腺癌中的作用研究进展 |
| Progress of Her-2 Expression in Gastroesophageal Junction Adenocarcinomas |
| 投稿时间：2014-09-17 |
| DOI：10.11735/j.issn.1004-0242.2015.01.A011 |
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| 中文关键词: 食管胃结合部腺癌 人类表皮生长因子受体2 综合治疗 |
| 英文关键词:gastroesophageal junction adenocarcinomas human epidermal growth factor receptor 2 comprehensive therapy |
| 基金项目:浙江省自然科学基金（LY13H290013）； |
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| 中文摘要: |
| 摘 要：近几十年来，食管胃结合部腺癌的发病率正在逐年上升。Her-2表达与食管胃结合部腺癌预后的研究结果呈现争议，研究认为这是因为Her-2检测的局限性和组织标本的异质性而导致不同的结果。对于Her-2过表达的食管胃结合部腺癌，综合治疗包括新辅助放化疗、辅助放化疗、手术治疗及靶向治疗在临床疗效中的地位越来越突出，中医药治疗也在辅助治疗中起到重要作用。 |
| 英文摘要: |
| Abstract：In recent decades，the incidence of gastroesophageal junction（GEJ）adenocarcinomas is increasing. The relationship between Her-2 expression and prognosis of GEJ adenocarcinomas shows controversy. It leads to different results because of Her-2 detection limitations and tissue heterogeneity. For GEJ adenocarcinomas with Her-2 overexpression，comprehensive therapy including neoadjuvant chemotherapy，adjuvant radiotherapy，surgery and targeted therapy is becoming more and more prominent in the clinic. Traditional Chinese medicine has played an important role in the adjuvant therapy. |
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