| 全雄男,MEIHUA PIAO,胡早秀.延边地区胃癌中TP和COX-2表达及其临床意义[J].中国肿瘤,2014,23(12):1034-1038. |
| 延边地区胃癌中TP和COX-2表达及其临床意义 |
| Expression of TP and COX-2 in Gastric Cancer and Its Significance in Yanbian Region，Jilin Province |
| 投稿时间：2014-02-18 |
| DOI：10.11735/j.issn.1004-0242.2014.12.A016 |
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| 中文关键词: 胃癌 胸苷磷酸化酶 环氧合酶-2 预后 |
| 英文关键词:gastric cancer thymidine phosphorylase cycloxygenase-2 prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨TP和COX-2在胃癌中的表达及其临床意义。［方法］ 采用免疫组化方法检测TP和COX-2在50例胃癌中的表达，分析其与胃癌临床病理特征及预后的关系。［结果］ TP和COX-2在胃癌中的阳性表达率分别为56.0% (28/50)和62.0% (31/50)。TP蛋白表达与胃癌的分化程度、浸润深度和淋巴结转移相关（P＜0.05）；COX-2蛋白表达与胃癌淋巴结转移相关（P＜0.05）。胃癌组织中TP和COX-2的表达呈正相关（χ2=4.565，P＜0.05）。TP表达阳性和阴性者的5年生存率分别为25.0%和54.5%（P＜0.05）；COX-2表达阳性和阴性者的5年生存率分别为22.6%和63.2%（P＜0.05）。［结论］ TP和COX-2在胃癌的发生发展中可能起重要作用，可作为预测胃癌预后的指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of TP and COX-2 in gastric cancer and its clinical significance.［Methods］ The expression of TP and COX-2 in 50 cases with gastric cancer was detected by immunohistochemistry method. The relationship of TP and COX-2 expression with the clinicopathological features and prognosis were analyzed.［Results］ The positive rate of TP and COX-2 in gastric cancer was 56.0% (28/50) and 62.0% (31/50) respectively. The expression of TP in gastric cancer tissue related to differentiation，invasion and lymph node metastasis (P<0.05). The expression of COX-2 related to lymph node metastasis(P<0.05). Positive correlation was found between TP expression and COX-2 expression in gastric cancer tissues(χ2=4.565，P＜0.05). The 5 year survival in patients with positive and negative expressions of TP was 25.0% and 54.5%(P＜0.05)，and it in patients with positive and negative expression of COX-2 was 22.6% and 63.2%(P＜0.05) respectively.［Conclusion］ TP and COX-2 might play an important role in carcinogenesis and progress of gastric cancer. Expression of them can be used as prognostic markers for gastric cancer. |
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