| 张 青,刘益飞,章建国.趋化因子受体CXCR7在非小细胞肺癌[J].中国肿瘤,2014,23(11):952-955. |
| 趋化因子受体CXCR7在非小细胞肺癌 |
| The Expression of Chemokine Receptor 7(CXCR7) in Non-small Cell Lung Cancer and its Clinical Significance |
| 投稿时间：2014-07-08 |
| DOI：10.11735/j.issn.1004-0242.2014.11.A017 |
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| 中文关键词: 非小细胞肺癌 CXCR7 免疫组织化学 |
| 英文关键词:non-small cell lung carcinoma CXCR7 immunohistochemistry |
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| 中文摘要: |
| 摘 要：［目的］ 研究趋化因子受体CXCR7在非小细胞肺癌（NSCLC）中的表达，并探讨其与NSCLC临床病理特征的关系。［方法］ 采用免疫组织化学Envision法检测120例NSCLC癌组织及20例正常肺组织中CXCR7的表达。［结果］ 在NSCLC癌组织中，CXCR7阳性表达率为59.2%(71/120)，在正常肺组织中CXCR7阳性表达率为10.0%（2/20）（P＜0.05）。CXCR7阳性表达与癌组织分化程度和淋巴结转移有关（P＜0.05）。CXCR7阳性表达组与阴性表达组5年生存率分别为11.3%和22.4%（P＜0.05）。［结论］ CXCR7可能参与了NSCLC的发生发展和淋巴结转移。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of the chemokine receptor 7(CXCR7)，and the relationship between CXCR7expression and clinical feature in patients with non-small cell lung cancer.［Methods］ Expression of CXCR7 in 120 patients with NSCLC and 20 specimens of normal lung tissues were detected by immunohistochemical technique.［Results］ The positive expression rate of CXCR7 were 59.2%(71/120) in the NSCLC cancer tissues and 10%(2/20) in normal lung tissues. The positive expression of CXCR7 in NSCLC was significantly higher than that in the normal lung tissues(P＜0.05). Positive expression of CXCR7 related to tumor grade and lymphatic metastasis(P＜0.05). The 5 year survival rate was 11.3% in patients with positive expression of CXCR7，and 22.4% in patients with negative expression of CXCR7 (P＜0.05). ［Conclusions］ CXCR7 might participate in tumor oncogenesis，progress and lymph node metastasis of NSCLC. |
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