| 邓 瑛,陈志梅,陈 彬.人乳头瘤病毒经产道母婴垂直传播的分析[J].中国肿瘤,2014,23(11):913-916. |
| 人乳头瘤病毒经产道母婴垂直传播的分析 |
| An Analysis of Vertical Transmission of Human Papillomavirus through the Birth Canal |
| 投稿时间：2014-07-30 |
| DOI：10.11735/j.issn.1004-0242.2014.11.A007 |
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| 中文关键词: 人乳头瘤病毒 垂直传播 妊娠妇女 |
| 英文关键词:human papillomavirus vertical transmission woman |
| 基金项目:深圳市科技计划项目（201103196） |
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| 中文摘要: |
| 摘 要：［目的］ 分析人乳头瘤病毒经产道母婴垂直传播的特点。［方法］ 应用PCR体外扩增和DNA反向斑点杂交相结合的DNA芯片技术，对经产道分娩产妇及其新生儿117对（自然分娩组）和剖宫产产妇及其新生儿74对（剖宫产组）母体生殖道、新生儿口腔分泌物进行HPV定性及分型检测。［结果］ 母体生殖道HPV检出率为14.66%（28/191）；自然分娩组和剖宫产组的新生婴儿口腔HPV检出率分别为3.42%和0.00%，但差异无统计学意义（P>0.05）。母体生殖道HPV阳性者新生婴儿口腔HPV检出率为22.22%（4/18），显著性高于母体生殖道HPV阴性组的检出率（0，0/99）（P＜0.05）。新生婴儿口腔HPV亚型与其母体生殖道的亚型一致。［结论］ 妊娠妇女生殖道HPV感染较为常见，HPV可以经产道垂直传播，对母体及新生儿的影响值得进一步研究。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the features of human papillomavirus vertical transmission through the birth canal. ［Methods］ A total of 117 pairs of natural delivery mothers and their newborns (natural childbirth group) and 74 pairs of cesarean mothers and their newborns(C-S group) were recruited. HPV were examined and genotyped by polymerase chain reaction(PCR) and reversed dot blot hybridization for secretion from maternal genital tract and newborn oral.［Results］ HPV detection rate of maternal genital tract was 14.66%(28/191). Newborn oral HPV detection rate in natural childbirth group and C-S group was 3.42% and 0.00% respectively，with no statistic difference( P>0.05）. Oral HPV detection rate of newborns in genital tract HPV-positive mothers was 22.22%（4/18），which was significantly higher than that in genital tract HPV-negative mothers(0，0/99）（P＜0.05). Genotyping showed newborn oral HPV subtypes were coincidence with their mother’s genital tract subtypes. ［Conclusion］ Pregnant women genital HPV infection is common. HPV can be vertical transmitted through the birth canal. HPV impact on mother and newborn deserves further study. |
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