| 丁丹红,王修身,卜珊珊.无功能性胃肠胰神经内分泌肿瘤的临床特征和预后分析[J].中国肿瘤,2014,23(9):785-789. |
| 无功能性胃肠胰神经内分泌肿瘤的临床特征和预后分析 |
| Analysis of Clinical Feature and Prognosis of Nonfunctional Gastroenteropancreatic Neuroendocrine Neoplasm |
| 投稿时间：2014-03-06 |
| DOI：10.11735/j.issn.1004-0242.2014.09.A017 |
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| 中文关键词: 胃肠道 胰腺 神经内分泌肿瘤 预后 |
| 英文关键词:gastrointestinal tract pancreatic neuroendocrine neoplasm prognosis |
| 基金项目: |
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| 摘要点击次数: 2006 |
| 全文下载次数: 1078 |
| 中文摘要: |
| 摘 要：［目的］ 探讨无功能性胃肠胰神经内分泌肿瘤的临床病理特征，并分析影响其预后的因素。［方法］ 回顾性分析河南省肿瘤医院2004年7月至2012年5月收治的73例无功能性胃肠胰神经内分泌肿瘤临床资料。［结果］ 全组患者的3、5年生存率分别为76.9%和40.5%。其中神经内分泌瘤(NET)、神经内分泌癌(NEC)、混合型腺—神经内分泌癌(MANEC)的3年和5年生存率分别为87.5%和50.0%、29.0%和18.1%、40.6%和10.2%。单因素分析显示年龄、性别、病理类型、TNM分期、发病部位和治疗方式是影响预后的因素。Cox多因素分析显示TNM分期和性别是影响预后的独立因素。［结论］ 女性、年轻、临床分期早、肿瘤级别低是影响无功能性胃肠胰神经内分泌肿瘤预后的有利因素。TNM分期和性别是影响预后的独立因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinical feature and prognosis of nonfunctional gastroenteropancreatic neuroendocrine neoplasm(NF-GEP-NEN). ［Methods］ The data of 73 patients with NF-GEP-NEN treated in Henan Cancer Hospital from July 2004 to May 2012 were retrospectively reviewed. ［Results］ The 3-year and 5-year survival rates were 76.9% and 40.5% respectively in enrolled patients. The 3-year and 5-year survival of NET，NEC and MANEC were 87.5% and 50.0%，29.0% and 18.1%，40.6% and 10.2% respectively. Single-factor analysis showed that age，gender，pathological type，TNM stage，tumor location and treatment method were the factors affecting prognosis of patient with NF-GEP-NEN. Cox multivariate analysis revealed that TNM stage and gender significantly affected prognosis of NF-GEP-NEN. ［Conclusions］ Women，young，early clinical stage and low grade tumor are the favorable factors in patient with NF-GEP-NEN. TNM staging and gender were the independent prognostic factors. |
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