| 曲宝林,俞 伟,王 卉.18F-FLT和18F-FDG PET显像评价肺大细胞癌放疗疗效的实验研究[J].中国肿瘤,2014,23(9):779-784. |
| 18F-FLT和18F-FDG PET显像评价肺大细胞癌放疗疗效的实验研究 |
| Experimental Research of 18F-FLT and 18F-FDG PET Imaging for Evaluating Response to Radiotherapy in Large-Cell Lung Carcinoma |
| 投稿时间：2013-12-27 |
| DOI：10.11735/j.issn.1004-0242.2014.09.A016 |
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| 中文关键词: 18F-FLT 18F-FDG 细胞增殖 肺大细胞癌 |
| 英文关键词:18F-FLT 18F-FDG tumor proliferation lung large cell carcinoma |
| 基金项目:北京科学技术委员会首都临床特色应用研究 |
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| 中文摘要: |
| 摘 要：［目的］ 评价18F-FLT和18F-FDG PET显像在早期评价肺大细胞癌放疗疗效中的作用。［方法］ 18只荷肺大细胞癌小鼠随机分为18F-FLT和18F-FDG两组，各组又随机配对分为A组、B组、C组，每组3只。A组为对照组，未进行任何治疗；B组于实验前1d对小鼠肿瘤部位进行放疗，单次剂量X线2000cGy，能量6MV；C组于实验前2d同样对小鼠肿瘤部位进行放疗，放疗剂量同B组。经小鼠尾静脉注入18F-FLT和18F-FDG后行MicroPET显像，于注射后60min进行PET显像。［结果］ 放疗后肺大细胞癌18F-FLT摄取较对照组明显降低（1.33%±0.27％和0.58%±0.08%，P<0.05），FDG组FDG摄取放疗后48h与对照组比较有显著性差异（P<0.05）。PET显像FLT组在放疗后24h、48h后T/NT值明显低于对照组（P<0.05），而FDG放疗组48h与对照组相比有统计学差异（P<0.05）。［结论］ 18F-FLT可被肺部恶性肿瘤摄取，其特异度高于18F-FDG。放疗引起的18F-FLT摄取变化较18F-FDG灵敏，放疗后18F-FLT摄取降低较18F-FDG明显，因而18F-FLT是一种监测恶性肿瘤放疗疗效的有效的示踪剂。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the role of 18F-fluorothymidine(18F-FLT) and 18F-fluorodeoxyglucose(18F-FDG) position emission tomography(PET) imaging for evaluating the efficacy of radiotherapy for large-cell lung carcinoma. ［Methods］ Eighteen mice bearing lung large cell carcinoma were randomly divided into two groups according to the different tracers(18F-FLT and 18F-FDG)，each group was further randomly divided into three sub-groups，group A was control group，group B was treated with 6MV X-ray irradiation of 2000cGy one fraction in the first day and group C in the second day before the experiment. All mice were injected with 18F-FLT or 18F-FDG by tail vein. At 60min after tracers injection，biodistribution and PET imaging were performed.［Results］ 18F-FLT uptake in murine model of lung large cell carcinoma after irradiation was significantly lower than that of control group (1.33%±0.27％，0.58%±0.08%，P<0.05)；18F-FDG uptake after irradiation 48h was significantly lower than that of control group. PET imaging after radiotherapy 24h and 48h，the T/NT value in FLT group was significantly lower than that in control group(P<0.05)， while the T/NT value in FLT group was significantly lower than that in control group after 48h(P<0.05).［Conclusion］ The uptake of 18F-FLT in pulmonary malignant tissues is higher than that in normal tissues，thus the pulmonary neoplasm can be identified accurately with PET imaging. The decrease in tumor 18F-FLT uptake after radiotherapy was more pronounced than that of 18F-FDG. Therefore，18F-FLT is a promising PET tracer for monitoring response to radiotherapy in oncology. |
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