| 张志镒,吴正奇,卢林芝.2009~2012年武威市凉州区上消化道癌筛查结果分析[J].中国肿瘤,2014,23(9):743-747. |
| 2009~2012年武威市凉州区上消化道癌筛查结果分析 |
| Analysis on Screening for Upper Gastrointestinal Cancer in Liangzhou District，Wuwei City，Gansu Province，2009 ~2012 |
| 投稿时间：2014-04-26 |
| DOI：10.11735/j.issn.1004-0242.2014.09.A008 |
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| 中文关键词: 食管癌 胃癌 癌前病变 胃蛋白酶原类 |
| 英文关键词:esophageal cancer gastric cancer precancerous lesions pepsinogen classes |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 分析2009~2012年武威市凉州区上消化道癌（食管癌、胃癌）筛查情况。［方法］ 采用流行病学调查、血清PG检测、内镜活检和病理检查的方法，对武威市凉州区40~69岁无症状、有上消化道病史、食管癌和胃癌家族史志愿者进行上消化道癌筛查。［结果］ 本组筛查共8007人，上消化道癌总检出率为1.80%（144/8007），食管癌检出率为0.54%（43/8007），胃癌检出率为1.26%（101/8007）。上消化道癌早诊率为72.22%（104/144）。2009~2010年PG检测3507人，PG阳性组（n=1307）中胃癌和高级别上皮内瘤变检出率分别为0.84%（11/1307）、0.31%（4/1307）；而PG阴性组中（n=2200）则分别为0.36%（8/2200）、0.14%（3/2200）。PG阳性与PG阴性组间胃癌及其癌前病变检出率差异有显著性（P＜0.01）。3507人检出重度异型增生/原位癌及食管癌14例，其中PG阴性检出食管癌4例，重度异型增生/原位癌2例；PG阳性组中检出食管癌4例，重度异型增生/原位癌4例。 ［结论］ 在上消化道癌高发区直接应用内镜对上消化道癌进行筛查，才能最大限度地降低上消化道癌的漏诊。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the results of screening for upper gastrointestinal cancer（esophageal cancer，gastric cancer） in Liangzhou district，Wuwei city from 2009~2012. ［Methods］ The people（40~69 years） with history of upper gastrointestinal tract disease，esophageal and gastric cancer family history in Liangzhou district，Wuwei city were screened by using epidemiological investigation，serum PG detection，endoscopic biopsy and pathological examination.［Results］ Of 8007 screened people，the detection rate of digestive tract cancer was 1.80%（144/8007），the detection rate of esophageal cancer and gastric cancer was 0.54%（43/8007），1.26%（101/8007） respectively. The early detection rate of upper gastrointestinal cancer was 72.22%（104/144）. A total of 3507 person were detected with PG，the detection rate of gastric carcinoma and high-grade intraepithelial neoplasia was 0.84%（11/1307），0.31%（4/1307） in PG positive group（n=1307），0.36%（8/2200），0.14%（3/2200） in PG negative group（n=2200） respectively，there were significant difference between PG positive and PG negative group（P<0.01）. Of 3507 people，14 cases with severe hyperplasia/cancer and esophageal carcinoma were found，including 4 cases of esophageal carcinoma and 2 cases of severe hyperplasia/carcinoma in situ in PG negative group，4 cases of esophageal carcinoma and 4 cases of severe hyperplasia/carcinoma in situ in PG positive group. ［Conclusions］ Application of endoscopic screening for upper gastrointestinal cancer in high risk region，can maximum reduce the missed diagnosis of upper gastrointestinal tract cancer. |
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