| 陈志霄,张铁宁,胡 烨.Ⅰ～ⅡA/B期睾丸精原细胞瘤诊治及放疗进展[J].中国肿瘤,2014,23(6):509-513. |
| Ⅰ～ⅡA/B期睾丸精原细胞瘤诊治及放疗进展 |
| Diagnosis and Radiotherapy for Patients with Testicular Seminoma Stages Ⅰand ⅡA/B |
| 投稿时间：2013-07-01 |
| DOI：10.11735/j.issn.1004-0242.2014.06.A014 |
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| 中文关键词: 睾丸精原细胞瘤 放射治疗 诊断 |
| 英文关键词:testicular seminoma radiotherapy diagnosis |
| 基金项目: |
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| 中文摘要: |
| 摘 要：睾丸精原细胞瘤是青壮年男性的好发肿瘤之一。过去放疗一直是Ⅰ期及ⅡA/B期精原细胞瘤的术后标准治疗；但近年来Ⅰ期患者术后，密切随访、放疗、化疗均为可接受方案。ⅡA期术后标准治疗是放疗，ⅡB期可放疗或化疗。对于放疗患者，Ⅰ期可行单纯腹主动脉旁照射，或腹主动脉旁+同侧髂淋巴结区照射，剂量20Gy/10次，2周。Ⅱ期行腹主动脉旁+同侧髂淋巴结区照射20Gy/10次，2周，结束后针对病灶缩野加量至30Gy/15次，3周至36Gy/18次，3.6周。 |
| 英文摘要: |
| Abstract：Testicular seminoma constitutes an important group of malignancies in young men. Although radiotherapy had been the standard treatment of seminoma patients clinical stage Ⅰand ⅡA/B in the past years，there is growing recognition that adjuvant radiotherapy is associated with an increased risk of late toxicity. In stage Ⅰ disease，it is recommended that patients should be informed of all treatment options，including surveillance，radiotherapy，or chemotherapy. In stage ⅡA disease，radiotherapy should be considered standard treatment if there are no contraindications. Otherwise，chemotherapy is an option. In stage ⅡB disease，chemotherapy or radiotherapy is reasonable treatment approach. The stage Ⅰ patients who choose adjuvant chemotherapy may be considered for(1) para-aortic RT to 20 Gy in 10 fractions over 2 weeks，or (2) classic dog-leg RT to 20 Gy in 10 fractions over 2 weeks. For stage ⅡA or ⅡB patients，dog-leg radiotherapy to 20 Gy in 10 fractions over 2 weeks followed by a 10 Gy in 15 fractions over 3 weeks boost to the adenopathy or a 16 Gy in 18 fractions over 3 weeks boost has been the standard treatment. |
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