| 俞庆宏,沈一平,叶宝东.小剂量HA方案治疗老年急性髓细胞性白血病临床观察[J].中国肿瘤,2014,23(5):435-437. |
| 小剂量HA方案治疗老年急性髓细胞性白血病临床观察 |
| Clinical Observation of Low-dose HA Regimen in the Treatment for Elderly Patients with Acute Myeloid Leukemia |
| 投稿时间：2013-12-20 |
| DOI：10.11735/j.issn.1004-0242.2014.05.A019 |
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| 中文关键词: 小剂量HA方案 急性髓细胞性白血病 老年人 疗效 |
| 英文关键词:low-dose HA regimen acute myeloid leukemia elderly efficacy |
| 基金项目:国家中医临床研究基地业务建设科研专项（“抗白延年汤”联合小剂量化疗治疗老年急性髓系白血病的临床研究）的组成部分（DZX2012176），临床注册号：Chi-CTR-TRC-13003671 |
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| 中文摘要: |
| 摘 要：［目的］ 研究小剂量 HA方案治疗老年急性髓细胞白血病( AML) 的临床疗效及安全性。［方法］ 应用小剂量HA方案(高三尖杉酯碱每天1mg，静脉滴注，第1～14d；阿糖胞苷12.5mg，皮下注射每12h一次，第1～14d；4周为1个疗程）治疗初发的老年急性髓细胞性白血病患者10 例，1个疗程后观察疗效及毒副反应。［结果］ 10例患者中，完全缓解6例(60%)，部分缓解1例(10%)，总有效率为70%。骨髓抑制相对较轻，未见严重的非血液系统毒副反应。［结论］ 小剂量HA方案诱导缓解治疗老年AML具有较好的有效率，毒副反应耐受较好，可作为年龄较大、一般状况较差、有多种或较重合并症的老年AML患者的初始治疗方案选择。 |
| 英文摘要: |
| Abstract:［Purpose］ To observe the efficacy and toxicity of low-dose HA regimen (homoharringtonine and cytarabine) for elderly acute myeloid leukemia. ［Methods］ A total of 10 untreated AML elderly patients were treated by the low-dose HA regimen ( homoharringtonine 1mg iv qd，days 1～14；cytarabine 12.5mg ih q12h，days 1～14，4 weeks as a cycle).The clinical response was assessed after 1 cycles of chemotherapy.［Results］ Of the 10 cases，6 cases achieved complete remission(CR)；1 case， partial remission(PR)；and 3 cases，non-remission(NR). The total remission rate was 70%.Myelosuppression was the most frequent toxicity，it was mild relatively，no severe non-hematologic toxicity was occurred.［Conclusion］ Low-dose HA regimen achieves a better response for elderly AML patients with acceptable toxicity. It could be a choice of the initial therapeutic regimen for eiderly AML patients with severe complication or poor performance status. |
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