| 江 慧,宋 纯,张桂荣.HER2阳性胃癌临床病理特征分析[J].中国肿瘤,2014,23(5):421-425. |
| HER2阳性胃癌临床病理特征分析 |
| Clinicopathological Characteristics of HER2-positive Gastric Cancer |
| 投稿时间：2013-08-28 |
| DOI：10.11735/j.issn.1004-0242.2014.05.A016 |
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| 中文关键词: 胃癌 HER2 免疫组织化学法 荧光原位杂交 |
| 英文关键词:gastric cancer HER2 immunohistochemistry fluorescence in situ hybridization |
| 基金项目:辽宁省医学高峰建设工程项目（2010077）；辽宁省博士科研启动基金项目（20101059） |
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| 中文摘要: |
| 摘 要：［目的］ 分析胃癌HER2阳性率，探讨HER2阳性胃癌临床病理特征。［方法］ 采用免疫组织化学法（IHC）检测HER2蛋白表达，采用荧光原位杂交（FISH）检测HER2基因扩增。［结果］ 110例胃癌组织HER2 IHC阳性率为6.4%（7/110），FISH阳性率为14.5%（16/110）。排除IHC2+，IHC与FISH检测结果符合率为96%。HER2总体阳性率为10.9%。Lauren分型肠型胃癌HER2阳性率高于混合型和弥漫型（18.0% vs 5.0%，P＜0.05）。WHO分型管状腺癌HER2阳性率高于其他类型（19.3% vs 2.3%，P＜0.05），中、高分化胃癌HER2阳性率高于低分化胃癌（20.0% vs 5.7%，P＜0.05）。HER2阳性率在不同年龄、性别、肿瘤部位、肿瘤大小、淋巴结转移和TNM分期胃癌中无统计学差异（P＞0.05）。［结论］ 胃癌HER2阳性与Lauren分型及WHO分型、分级有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the positive rate of HER2 in gastric cancer and the clinicopathologic characteristics of HER2-positive gastric cancer.［Methods］ HER2 expression was detected by immunohistochemistry (IHC). HER2 gene amplification was analyzed by fluorescence in situ hybridization(FISH). ［Results］ In 110 cases of gastric cancer，positive rates of HER2 IHC and FISH testing were 6.4% (7/110) and 14.5% (16/110) respectively. A coincidence rate of 96% between IHC and FISH results was demonstrated when IHC2+ was excluded. The overall HER2 positive rate was 10.9%. Intestinal type gastric carcinomas by Lauren’s classification showed significantly higher HER2 positive rate than that in mixed and diffuse types(18.0% vs 5.0%，P＜0.05). Tubular adenocarcinoma by WHO classification revealed markedly higher HER2 positive rate than that in others(19.3% vs 2.3%，P＜0.05). HER2 positive rate in well and moderately differentiated gastric cancer was significantly higher than that in poorly differentiated type(20.0% vs 5.7%，P＜0.05). There was no statistical differences in HER2 positive rates in gastric cancer subgroups stratified by age，gender，tumor location，tumor size，lymph node metastasis or TNM stages (P＞0.05). ［Conclusion］ HER2-positive is associated with Lauren classification and WHO classification/differentiation in gastric cancer. |
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