| 谌海燕,刘朝阳,陈信义.复方浙贝颗粒联合三苯氧胺对LCC2移植瘤的抑制作用及对血清TGF-β1的影响[J].中国肿瘤,2014,23(5):412-416. |
| 复方浙贝颗粒联合三苯氧胺对LCC2移植瘤的抑制作用及对血清TGF-β1的影响 |
| Effect of Inhibition and Serum TGF-β1 Concentrations of LCC2 xenografts by Compound Zhe Bei Granule Combined with Tamoxifen |
| 投稿时间：2013-11-03 |
| DOI：10.11735/j.issn.1004-0242.2014.05.A014 |
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| 中文关键词: 复方浙贝颗粒 三苯氧胺 LCC2细胞 移植瘤 TGF-β1 |
| 英文关键词:compound Zhe Bei granule tamoxifen LCC2 cells xenografts TGF-β1 |
| 基金项目:北京中医药大学自主创新课题(2009TYBZZ-XS057) |
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| 中文摘要: |
| 摘 要：［目的］ 研究复方浙贝颗粒（CZBG）联合三苯氧胺（TAM）对LCC2移植瘤的抑制作用及对血清TGF-β1的影响。［方法］ 建立耐TAM乳腺癌细胞的LCC2动物移植瘤模型，将动物分为对照组、TAM组、阿霉素（ADM）+TAM组、CZBG+TAM组、ADM+CZBG+TAM组，分别比较各组瘤重，肝、脾、子宫脏器指数及血清TGF-β1浓度差异。［结果］ CZBG+TAM、ADM+TAM的抑瘤率分别为54.25%和52.05%。CZBG+TAM与单纯TAM组相比较，子宫指数有所降低（F=4.742，P＜0.05）。CZBG+TAM组和ADM+ CZBG+TAM组血清TGF-β1浓度分别为482.95±80.44pg/ml和416.08±76.19pg/ml，与对照组(153.76±55.02) pg/ml相比差异具有统计学意义（F=4.683，P＜0.05）。［结论］ CZBG能够提高TAM对LCC2移植瘤的抑制率，并且可能通过升高血清TGF-β1浓度来抑制肿瘤生长。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the inhibitive effect of compound Zhe Bei granule（CZBG） combined with tamoxifen（TAM） on LCC2 xenografts and its influence on serum TGF-β1. ［Methods］ Xenograft model by using human breast cancer cells LCC2 resistant to TAM were made. Then the mice were randomly divided into control group，simple TAM group，adriamycin(ADM)+TAM group，CZBG+TAM group and ADM+CZBG+TAM group. The difference of tumor weight，liver，spleen，uterus organ index and serum levels of TGF-β1 among the groups were compared.［Results］ The tumor inhibition rates of CZBG+TAM group and ADM+TAM group were 54.25%，52.05% respectively. Uterus index was lower in CZBG+TAM group compared with simple TAM group(F=4.742，P＜0.05). The serum concentrations of TGF-β1 in CZBG+TAM group and ADM+CZBG+TAM group were 482.95±80.44pg/ml，416.08±76.19pg/ml respectively，which were statistically different compared with control group(153.76±55.02 pg/ml )(F=4.683，P＜0.05). ［Conclusions］ CZBG can improve the tumor inhibition rate of LCC2 xenografts. In addition，it could increase inhibition of tumor growth through increasing serum TGF-β1 concentration. |
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