| 刘 雷,吴志宏,章载良.ARHⅠ和E钙粘蛋白在乳头状甲状腺癌中的表达及意义[J].中国肿瘤,2014,23(4):333-337. |
| ARHⅠ和E钙粘蛋白在乳头状甲状腺癌中的表达及意义 |
| Expression of ARHⅠ and E-cadherin Proteins in Papillary Thyroid Carcinoma and Its significance |
| 投稿时间：2013-11-05 |
| DOI：10.11735/j.issn.1004-0242.2014.04.A013 |
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| 中文关键词: ARHⅠ E钙粘蛋白 乳头状甲状腺癌 印迹抑癌基因 |
| 英文关键词:ARHⅠ E-cadherin papillary thyroid carcinoma imprinted tumor suppressor gene |
| 基金项目:浙江省湖州市自然科学基金项目（2012YZ15） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨ARHⅠ蛋白及E钙粘蛋白在乳头状甲状腺癌中的表达及意义。［方法］ 56例经病理确诊的乳头状甲状腺癌患者入组，并取其距癌组织边缘＞2cm的正常甲状腺组织作为对照。采用免疫组化方法检测ARHⅠ蛋白及E钙粘蛋白的表达。［结果］ ARHⅠ及 E钙粘蛋白在乳头状甲状腺癌中的表达均显著低于正常甲状腺组织（48.2% vs 80.4%，51.8% vs 91.1%，P均<0.05）。ARHⅠ、E钙粘蛋白在乳头状甲状腺癌中的表达与肿瘤大小、TNM分期、淋巴结转移情况有关(P<0.05）。ARHⅠ与E钙粘蛋白在乳头状甲状腺癌中的表达无明显相关性（Kappa=0.287，P=0.023）。［结论］ ARHⅠ、E钙粘蛋白在乳头状甲状腺癌中表达降低，提示其在乳头状甲状腺癌的发生发展、侵袭中可能发挥重要作用。 |
| 英文摘要: |
| Abstract：［Purpose］To investigate the expression of ARHⅠand E-cadherin proteins in papillary thyroid carcinoma (PTC) and its significance.［Methods］ Fifty-six cases with PTC pathologically proved were enrolled，and their matched normal thyroid tissue (beyond 2.0cm from the tumor edge) as control group. Expression of ARHⅠ and E-cadherin was detected by immunohistochemical staining. ［Results］ The expression of ARHⅠ and E-cadherin in PTC were significantly lower than those in normal thyroid tissue（48.2% vs 80.4%，51.8% vs 91.1%，all P <0.05）. Expressions of ARHⅠand E-cadherin were all related to tumor size，TNM staging and lymph node metastasis of PTC. There was a negative correlation between the ARHⅠand E-cadherin expression in PTC (Kappa=0.287，P=0.023).［Conclusions］ ARHⅠand E-cadherin proteins are low-expression in PTC. They may play an important role in carcinogenesis，progress，invasion and lymph node metastasis of PTC. |
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