| 刘阳云,刘庚勋,李正贤.VEGF表达预测鼻咽癌放疗效应的价值[J].中国肿瘤,2014,23(4):329-332. |
| VEGF表达预测鼻咽癌放疗效应的价值 |
| The Value of VEGF Expression to Predict the Effect of Radiotherapy in Patients with Nasopharyngeal Carcinoma |
| 投稿时间：2013-07-21 |
| DOI：10.11735/j.issn.1004-0242.2014.04.A012 |
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| 中文关键词: 血管内皮生长因子 鼻咽癌 放射治疗 |
| 英文关键词:VEGF nasopharyngeal carcinoma radiotherapy |
| 基金项目:湖南省卫生厅科研项目(C2012-009) |
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| 摘要点击次数: 1856 |
| 全文下载次数: 875 |
| 中文摘要: |
| 摘 要：［目的］ 探讨血管内皮生长因子(VEGF)预测鼻咽癌（NPC）放疗效应的价值。［方法］ 应用免疫组化法检测50例放射敏感和30例放射抵抗的鼻咽部低分化鳞状细胞癌在接受放疗前的肿瘤组织中VEGF的表达情况，分析VEGF的表达与放疗效应的关系。［结果］ VEGF在NPC中总的阳性表达率为58.75%（47/80）。在50例放射敏感的NPC组织中，33例(66.00%)VEGF阳性表达，在30例放射抵抗的NPC组织中，14例(46.67%)VEGF阳性表达；两组比较，差异无统计学意义(χ2=2.892，P=0.105)。根据VEGF阳性表达预测NPC放疗抵抗，其预测鼻咽癌放疗效应的敏感性46.67%，特异度34.00%，准确率38.75%。ROC曲线下面积为0.625（95%CI：0.491~0.760；P=0.062）。［结论］ 放疗前鼻咽部低分化鳞状细胞癌肿瘤组织中VEGF表达对预测放疗效应的价值有限。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the value of vascular endothelial growth factor(VEGF) expression to predict the effect of radiotherapy in patients with nasopharyngeal carcinoma(NPC). ［Methods］ The expression of VEGF protein in 50 radiosensitive tissue samples and 30 tissue samples radioresistant with poorly differentiated NPC(before radiotherapy) were detected by immunohistochemical staining (SP method).The association of the expression of VEGF and the effect of radiotherapy was analyzed.［Results］ The positive rates of VEGF expression in all NPC tissues were 58.75%(47/80). The positive rate of VEGF was 66.00%(33/50) and 46.67%(14/30) in radioresistant and radiosensitive NPC tissues，respectively，there was no statistical difference between the two groups(χ2=2.892，P=0.105).Based on the positive expression of VEGF to predict the effect of radiotherapy，the sensitivity，specificity and accuracy were 46.67%，34.00% and 38.75%，respectively. The area under ROC curve was 0.625(95%CI:0.49～0.76，P=0.062).［Conclusions］ The value of the VEGF expression as a marker for predicting response to radiotherapy was limited for NPC. |
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