| 毛伯能,钱 维,潘 琦.江苏宜兴地区大肠癌平均风险人群结肠镜筛查结果分析[J].中国肿瘤,2014,23(4):292-297. |
| 江苏宜兴地区大肠癌平均风险人群结肠镜筛查结果分析 |
| An Analysis of the Results from Colonoscopy Screening for Colorectal Cancer in Average-risk Individuals in Yixing Area，Jiangsu Province |
| 投稿时间：2013-09-06 |
| DOI：10.11735/j.issn.1004-0242.2014.04.A005 |
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| 中文关键词: 大肠癌 平均风险人群 结肠镜筛查 横断面研究 宜兴 |
| 英文关键词:colorectal neoplasms average-risk population colonoscopy screening cross-sectional studies Yixing |
| 基金项目:无锡市科学技术局项目（CSZ00N1248） |
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| 摘要点击次数: 2392 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨江苏宜兴地区平均风险人群中大肠肿瘤和大肠进展期肿瘤的发生情况和解剖部位分布情况。［方法］ 采用横断面研究设计。以江苏宜兴地区籍平均风险人群为研究对象，进行结肠镜检查。采用χ2检验比较不同性别、不同年龄组大肠肿瘤和大肠进展期肿瘤解剖学部位分布情况。采用Logistic回归分析方法比较不同年龄组大肠肿瘤和大肠进展期肿瘤的发生风险，并分析远端结肠病变对近端结肠病变的预测作用。［结果］ 共纳入905例合格研究对象，大肠肿瘤和进展期肿瘤的发生率分别为34.5%和5.3%。远端结肠发生肿瘤和进展期肿瘤的比例均高于近端结肠。男性发生大肠肿瘤和进展期肿瘤的风险明显高于女性（P<0.01）。随着年龄增长，大肠肿瘤和进展期肿瘤的发生风险均明显增加（P<0.01），远端结肠肿瘤和进展期肿瘤发生率增加的幅度均高于近端结肠。年龄增长与大肠肿瘤发生风险增加的关系主要表现在女性人群。在控制年龄、性别的影响后，远端结肠肿瘤患者发生近端结肠肿瘤的风险仍然明显高于远端结肠无病变者（OR=1.94，95%CI：1.30~2.88，P=0.001），说明远端结肠肿瘤病变对于近端结肠肿瘤具有预测作用；远端结肠进展期肿瘤病变对于近端结肠进展期肿瘤的预测作用不明显。［结论］ 本研究具有较强的科学性和较高的可信度。研究结果为制定该人群的大肠癌筛查策略提供了科学依据。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the prevalence rate and anatomic location of colorectal neoplasm and advanced colorectal neoplasm in a cohort of average-risk individuals in Yixing area，Jiangsu Province. ［Methods］ Cross-sectional study was conducted in this study. The average-risk persons in Yixing area of Jiangsu Province who had complete colonoscopy were included. Association of each factor (gender and age) with anatomic location of colorectal neoplasm and advanced colorectal neoplasm were performed by chi-square analyses. A logistic regression method was used to study the relationship between age and risks for colorectal neoplasm and advanced colorectal neoplasm，respectively. The risk for proximal neoplasm according to the distal findings was analyzed by logistic regression method. ［Results］ A total of 905 average-risk persons were included in this study. The prevalence rates of colorectal neoplasm and advanced neoplasm were 34.5% and 5.3%，respectively. The distal colon had higher prevalence rates of colorectal neoplasm and advanced neoplasm than the proximal colon. Prevalence was higher in men than that in women(P<0.01). The risks for colorectal neoplasm and advanced neoplasm increased significantly with age (P<0.01). After adjusted for age and gender，the risk for proximal colorectal neoplasm in the persons with distal colorectal neoplasm was higher than that in the persons without distal colorectal neoplasm(P=0.001). The distal colorectal neoplasm was a predictor for the proximal neoplasm. However，the distal advanced neoplasm was not a significant predictor for the proximal advanced neoplasm. ［Conclusion］ The results in this study were both scientific and credible，and will provide the basis for the formulation of colorectal cancer screening strategies. |
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