| 王 华,王宗平.膀胱癌溶瘤腺病毒治疗研究进展[J].中国肿瘤,2014,23(2):148-152. |
| 膀胱癌溶瘤腺病毒治疗研究进展 |
| Research Progress in Oncolytic Adenovirus in the Treatment for Bladder Cancer |
| 投稿时间：2013-11-12 |
| DOI：10.11735/j.issn.1004-0242.2014.02.A014 |
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| 中文关键词: 膀胱癌 溶瘤腺病毒 膀胱灌注 |
| 英文关键词:bladder cancer oncolytic adenovirus intravesical infusion therapy |
| 基金项目:浙江省钱江人才计划项目（2009R10001） |
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| 摘要点击次数: 1676 |
| 全文下载次数: 944 |
| 中文摘要: |
| 摘 要：膀胱癌是常见的恶性肿瘤，绝大多数为非肌层浸润性膀胱癌。目前，传统的治疗方法仍不能治愈所有膀胱癌患者，膀胱内灌注化疗药物和免疫制剂治疗后失败的膀胱癌缺乏有效的治疗方法。近年来，溶瘤腺病毒治疗肿瘤的研究大量报道，膀胱癌由于给药方便、局部给药不会引起全身毒副作用而成为溶瘤腺病毒治疗的理想癌种。全文综述溶瘤腺病毒膀胱内灌注治疗膀胱癌的研究进展。 |
| 英文摘要: |
| Abstract：Bladder cancer is a common malignancy. Most patients with bladder cancer are non-muscle invasion at initial diagnosis. At present，no therapy can cure all the patients with bladder cancer. Recently，oncolytic adenovirus therapies for tumor have been reported. Bladder cancer is an ideal target for viral therapy because viruses can be directly delivered，thus providing contact with the tumor and minimal dissemination to other sites. The advances of intravesical infusion therapy with oncolytic adenovirus for bladder cancer were reviewed in this article. |
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