| 乔洪源,陈建新,余宗阳.HGF及其c-MET受体在非小细胞肺癌中的研究进展[J].中国肿瘤,2014,23(2):141-147. |
| HGF及其c-MET受体在非小细胞肺癌中的研究进展 |
| Research Progress on HGF and c-MET Receptor in Non-small Cell Lung Cancer |
| 投稿时间：2013-07-01 |
| DOI：10.11735/j.issn.1004-0242.2014.02.A013 |
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| 中文关键词: HGF c-MET 非小细胞肺癌 靶向治疗 |
| 英文关键词:c-MET non-small cell lung cancer targeted therapy |
| 基金项目:国家自然科学基金（81274002） |
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| 中文摘要: |
| 摘 要：随着肿瘤分子生物学的飞速发展，分子靶向治疗已成为目前晚期肺癌治疗方法中最具前景的研究领域，因此分子靶点的研究也早已成为医学界关注的热点。近年来，研究发现HGF及其c-MET受体与非小细胞肺癌（non-small cell lung cancer，NSCLC）的发生、发展、组织学类型及预后密切相关。全文就HGF及其c-MET受体的结构、功能及其相关的靶向药物在NSCLC中的研究进展进行综述。 |
| 英文摘要: |
| Abstract：With the rapid development of tumor molecular biology，molecular targeted therapy has been the most promising area of research in the treatment of advanced lung cancer，so molecular targets also has become the focus of attention in the medical profession. In recent years，researchers found that HGF and c-MET receptor are associated with the occurrence，development，histological type and prognosis of non-small cell lung cancer(NSCLC). In this paper，the structure，function and correlative targeted drugs of HGF and c-MET receptor in NSCLC were comprehensively reviewed. |
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