| 毛盈颖,李迎君,陈 坤.散发性结直肠癌发病分子机制研究进展[J].中国肿瘤,2014,23(2):97-102. |
| 散发性结直肠癌发病分子机制研究进展 |
| Research Progress in Molecular Pathogenesis of Colorectal Cancer |
| 投稿时间：2013-10-24 |
| DOI：10.11735/j.issn.1004-0242.2014.02.A004 |
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| 中文关键词: 结直肠癌 发病机制 染色体不稳定 微卫星不稳定 CpG甲基化表型 |
| 英文关键词:colorectal cancer pathogenetic mechanisms chromosomal instability microsatellite instability CpG island methylator phenotype |
| 基金项目:国家自然科学基金（81072356，81373087） |
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| 摘要点击次数: 1621 |
| 全文下载次数: 966 |
| 中文摘要: |
| 摘 要：结直肠癌是最常见的消化系统恶性肿瘤之一，其病因和发病机制十分复杂。自1974年Morson提出结直肠腺瘤癌变序贯学说以来，随着现代分子生物学技术的飞速发展，研究者对结直肠癌发病的分子机制进行了深入研究。目前认为，结直肠癌的发生是一个多因素、多步骤、内外因交互作用的结果，且具有鲜明的分子特征，主要包括癌基因的激活、抑癌基因的失活及基因组不稳定现象等。全文主要围绕结直肠癌发病分子机制的最新研究进展作一综述。 |
| 英文摘要: |
| Abstract：Colorectal cancer(CRC) is one of the most common digestive system malignancies，and the etiological factors and pathogenetic mechanisms underlying CRC development appear to be complex and heterogeneous. Since Morson first proposed “the adenoma-carcinoma sequence” in 1974，the pathogenesis of CRC has been extensively studied with the rapid advancement of the molecular biological techniques. The development of CRC is recognized as a multi-factorial，multi-stage process with intense crosstalk of both genetic and environmental risk factors，and has distinct molecular characteristics，such as activation of oncogenes，loss-of-function of tumor suppressor genes，and genomic instability. In this review，the most up-to-date progresses in the study of molecular pathogenesis of CRC are discussed. |
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