| 曲 媛,车轶群,沈 迪.N2~3期鼻咽癌EGFR、VEGF、EBER表达与放化疗敏感性的关系[J].中国肿瘤,2014,23(1):72-76. |
| N2~3期鼻咽癌EGFR、VEGF、EBER表达与放化疗敏感性的关系 |
| Correlation of EGFR，VEGF and EBER With Chemoradiotherapy Sensitivity in Nasopharyngeal Carcinoma N2~3 |
| 投稿时间：2013-11-22 |
| DOI：10.11735/j.issn.1004-0242.2014.01.A017 |
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| 中文关键词: 鼻咽癌 EBER EGFR VEGF |
| 英文关键词:nasopharyngeal carcinoma EBER EGFR VEGF |
| 基金项目:北京希望马拉松专项 (LC2013B29) |
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| 摘要点击次数: 1913 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨N2~3期鼻咽癌EGFR、VEGF、EBER表达与放化疗敏感性间的关系。［方法］ 采用免疫组织化学方法研究143例经病理确诊的鼻咽癌患者组织EBER、EGFR和VEGF表达。定量PCR和酶联免疫吸附法（ELISA）检测92例N2~3期鼻咽癌患者血浆EB病毒游离DNA（EBV/DNA）、EGFR、VEGF的表达水平，并对92例N2~3期鼻咽癌随访2年。［结果］ N2~3期鼻咽癌EBER、EGFR及VEGF表达阳性率分别为97.8%(90/92)、95.7%(88/92)和35.9% (33/92)。 EBER表达与远处转移、复发及临床缓解相关，VEGF和EGFR表达强度与远处转移均呈正相关。N2~3期鼻咽癌患者血浆EBV/DNA、EGFR、VEGF治疗前与同步放化疗后比较差异均有统计学意义(P均<0.05)。血浆中EGFR和VEGF表达水平与远处转移相关。［结论］ 血浆和组织中EGFR和VEGF表达水平均可能与鼻咽癌远处转移相关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the correlation of EGFR，VEGF，EBER expression with chemoradiotherapy sensitivity in nasopharyngeal carcinoma(NPC) N2~3. ［Methods］ The expression of EGFR，VEGF and EBER protein was examined in 143 cases with NPC pathologically proven. Plasma VEGF & EGFR were detected by enzyme-linked immunosorbent assay(ELISA) and EB virus free DNA(EBV/DNA) was detected by real-time PCR in 92 patients with NPC N2~3 and followed-up 2 years.［Results］ The positive rate of EBER，EGFR and VEGF was 97.8%(90/92)，95.7%(88/92) and 35.9%(33/92) respectively in NPC cancer tissue. The level of EBER was correlated to distant metastasis，reurrence and clinical-remission(P<0.05). There was a positive correlation between VEGF，EGFR expression and distant metastasis. The plasma VEGF，EGFR and EBV/DNA levels of pretreatment were higher than those of post-treatment. The plasma EGFR and VEGF were correlated to distant metastasis.［Conclusion］ Expression of VEGF and EGFR in tissuses and plasma might be an early warming for distant metastasis. |
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