| 中文关键词: 恶性肿瘤 血管形成 分子调控 |
| 英文关键词:malignancy angiogenesis molecular regulator |
| 基金项目:浙江省自然科学基金（LY12H16032） |
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| 中文摘要: |
| 摘 要：恶性肿瘤最显著的表型是肿瘤细胞的失控性生长及异常血管增生。传统的手术、放疗及化疗主要是对恶性肿瘤细胞的杀伤和控制，但少有临床治愈。通过抑制血管形成可能治愈肿瘤的假设已日趋完整。近30年的研究表明，无论是生理性还是病理性血管形成，均是由约数十种经典及非经典的正性和负性调节因子共同参与、激活血管形成开关调控的。 |
| 英文摘要: |
| Abstract：The hallmarks of the malignancies are uncontrolled growth of tumor cells and excessive neovascularization. The traditional therapeutic modalities such as operation，radiotherapy and chemotherapy are based on the concept of killing tumor cells. However，rare tumors can be cured clinically. The hypothesis of anti-angiogenesis for treating tumor has been systemic and full of findings. The discovery of angiogenesis studies indicates that a number of classical and non-classical regulators，both positive and negative，form a complex regulation network and participate in the angiogenesis switch process. |
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