| 陈 峰,沈霞平,边林莉.TE方案与TEC方案在乳腺癌新辅助化疗中的疗效比较[J].中国肿瘤,2013,22(11):926-930. |
| TE方案与TEC方案在乳腺癌新辅助化疗中的疗效比较 |
| Comparion of TE Regimen and TEC Regimen in Neoadjuvant Chemotherapy for Breast Cancer |
| 投稿时间：2013-06-26 |
| DOI：10.11735/j.issn.1004-0242.2013.11.A019 |
|
 |
| 中文关键词: 乳腺癌 新辅助化疗 多西他赛 表阿霉素 |
| 英文关键词:breast cancer neoadjuvant chemotherapy docetaxel epirubicin |
| 基金项目: |
|
| 摘要点击次数: 1712 |
| 全文下载次数: 1083 |
| 中文摘要: |
| 摘 要：［目的］ 对比分析多西他赛联合表柔比星加/不加环磷酰胺（TEC/TE）两种新辅助化疗方案治疗乳腺癌的近期疗效。［方法］ 回顾性分析2006～2009年收治的Ⅱ～Ⅲ期乳腺癌新辅助化疗患者108例的临床病理资料，分别术前接受新辅助化疗的TE方案(n=62)及TEC方案(n=46)，两组患者均在术前接受2～4个周期化疗。TE方案：多西他赛 75mg/m2，第1天静脉滴注；表柔比星（EPI）60mg/m2，第1天静脉滴注。［结果］ 全组108例患者均可评价疗效，CR 10例（9.25%），PR 75例（69.44%）。TE组有效率为75.81%，而TEC组有效率为82.61%，两组有效率无统计学差异（?字2=0.729，P=0.392）。Ⅱ期患者28例均生存。Ⅲ期患者80例3年生存率为82.4%，其中TE组44例3年生存率为74.6%；而TEC组36例3年生存率为91.8%，差异有统计学意义（?字2=4.149，P=0.042）。［结论］ 在Ⅱ～Ⅲ期乳腺癌患者新辅助化疗中，TE与TEC方案近期疗效相似，TEC组3年生存率较佳，有待于进一步加大样本量进行研究。 |
| 英文摘要: |
| Abstract：［Purpose］ To compare the short-term efficacy of two neoadjuvant chemotherapy regimens：TE regimen(docetaxel，epirubicin) versus TEC regimen(docetaxel，epirubicin plus cyclophosphamide).［Methods］ The clinical data of 108 breast cancer patients with stage Ⅱ～Ⅲ from 2006 to 2009 were analyzed retrospectively. All the patients received neoadjuvant chemotherapy with TE(n=62) or TEC(n=46) regimen for 2~4 cycles before surgery. ［Results］ The assessments of 108 patients were available， 10 cases achieved CR(9.25%) and 75 cases achieved PR (69.44%). The response rate of TE group was 75.81%，and TEC group was 82.61% with no significant difference (?字2=0.729，P=0.392). Twenty-eight patients with stage Ⅱ were all survival during the follow-up. The 3-year overall survival in 80 patients stage Ⅲ was 82.4%， and 3-year overall survival in TE group(n=44) was 74.6% and 82.4% in TEC group (n=36) with significant difference(?字2=4.149，P=0.042). ［Conclusion］ The short-term efficacy of TE and TEC neoadjuvant chemotherapy regimens in stage Ⅱ～Ⅲ breast cancer patients are similar. The 3-year overall survival rate might be higher in TEC group. It should be further researched with larger samples. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |