| 谢颂平,左 涛,康敢军.趋化因子受体CXCR4和VEGF-C蛋白在食管癌组织中的表达及临床意义[J].中国肿瘤,2013,22(11):914-917. |
| 趋化因子受体CXCR4和VEGF-C蛋白在食管癌组织中的表达及临床意义 |
| Expressions of Chemokine Receptor CXCR4 and VEGF-C Protein in Esophageal Carcinoma and Their Significance |
| 投稿时间：2013-04-15 |
| DOI：10.11735/j.issn.1004-0242.2013.11.A016 |
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| 中文关键词: 食管癌 CXCR4 血管内皮生长因子 |
| 英文关键词:esophageal cancer CXCR4 VEGF-C |
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| 中文摘要: |
| 摘 要:［目的］ 探讨趋化因子受体(CXCR4)和血管内皮生长因子(VEGF-C)在食管癌组织中的表达情况，及其在食管癌发生、浸润、转移中的作用。［方法］ 应用免疫组织化学方法检测82例食管癌组织、20例正常食管组织中CXCR4、VEGF-C表达情况，并分析其与临床病理参数的关系。［结果］ CXCR4在82例食管癌组织中的阳性表达率为64.6%，CXCR4表达与食管癌患者年龄、性别无关（P>0.05），而与分化程度、病理类型、TNM 分期、浸润深度和淋巴结转移有相关性（P<0.05）。VEGF-C在82例食管癌组织中的阳性表达率为74.4%，VEGF-C表达与食管癌患者年龄、性别、分化程度和病理类型无关（P>0.05），而与TNM 分期、浸润深度和淋巴结转移有相关性（P<0.05）。［结论］ CXCR4和VEGF-C在食管癌组织中呈高表达，且与食管癌细胞侵袭、转移和淋巴结转移相关，在促进食管癌侵袭和转移中可能存在协同作用。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expressions of chemokine receptor（CXCR4）and vascular endothelial growth factor C（VEGF-C） in esophageal carcinoma tissues，and their roles in tumorigenesis，invasion and matastasis.［Methods］ Immunohistochemistry was applied to detect the expression of CXCR4 and VEGF-C in 82 samples of esophageal cancer tissue and 20 samples of normal esophageal tissue. The relationship between CXCR4，VEGF-C expression and the clinicopathological features were analyzed.［Results］ Positive expression rates of CXCR-4 and VEGF-C were 64.6% and 74.4% respectively in esophageal cancer tissue. CXCR4 correlated to pathologic grade，histological type，clinical staging，invasion depth and lymph node metastasis(P all<0.05)，but it did not correlate to gender and age(P>0.05)．VEGF-C correlated to clinical staging，invasion depth and lymph node metastasis(P all<0.05)，and did not correlate to gender，age，pathologic grade and histological type(P>0.05)．［Conclusion］ High expression of CXCR-4 and VEGF-C exists in esophageal cancer.CXCR-4 and VEGF-C might play symergistic effect in cancer metastasis，invasion and lymph node metastasis in esophageal cancer． |
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