| 王莹莹,马 骁,杨万水.2型糖尿病与消化系统恶性肿瘤队列研究的Meta分析[J].中国肿瘤,2013,22(11):845-857. |
| 2型糖尿病与消化系统恶性肿瘤队列研究的Meta分析 |
| A Meta-Analysis of Cohort Studies in Association with Type 2 Diabetes and Risk of Digestive System Cancer |
| 投稿时间：2013-05-03 |
| DOI：10.11735/j.issn.1004-0242.2013.11.A001 |
|
 |
| 中文关键词: 2型糖尿病 消化系统肿瘤 队列研究 Meta分析 |
| 英文关键词:type 2 diabetes digestive system cancer cohort studies Meta-analysis |
| 基金项目:国家科技重大专项基金资助（2008ZX10002-015， |
|
| 摘要点击次数: 2239 |
| 全文下载次数: 1674 |
| 中文摘要: |
| 摘 要：［目的］ 探讨2型糖尿病与消化系统恶性肿瘤的关系。［方法］ 利用 Medline、Embase与Web of Science检索2012年10月之前国外公开发表的关于2型糖尿病与消化系统恶性肿瘤关系的队列研究文献。利用R软件及其Meta程序包对检索结果进行综合分析。［结果］ 纳入分析的文献共41篇。经Meta分析后结果显示，2型糖尿病与消化系统恶性肿瘤间的相对危险度及95%可信区间为1.52 (95%CI:1.40~1.66)。2型糖尿病与肝癌、食管癌、胃癌、胰腺癌、结直肠癌以及结肠癌的关联均有统计学意义，合并相对危险度分别为1.79（95%CI:1.61~1.99），1.16（95%CI:1.07~1.27），1.34（95%CI:1.11~1.61），1.56（95%CI:1.49~1.64），1.32 （95%CI:1.23~1.40）和1.24（95%CI:1.15~1.33）。2型糖尿病与直肠癌合并相对危险度为1.07 （95%CI:0.91~1.25），无统计学意义。［结论］ 2型糖尿病与消化系统恶性肿瘤密切相关，可能是肝癌、食管癌、胃癌、胰腺癌、结肠癌的危险因素之一。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the relationship between type 2 diabetes and risk of digestive system cancer. ［Methods］ The articles of association between type 2 diabetes and the risk of digestive system cancer from the cohort studies form Medline，Embase and Web of Science before October 2012 were selected. A Meta-analysis was conducted to estimate the pooled relative risks (RR) by R software and its Meta package. ［Results］ A total of 41 articles were included in the Meta-analysis. In total，the pooled relative risk(RR) for digestive system cancer among patients with type 2 diabetes was 1.52(95%CI：1.40~1.66) compared to those non-diabetes. The results showed significantly increased risks for the common cancer sites of digestive system such as liver，esophagus，stomach，pancreas，colorectum and colon with the pooled RRs of 1.79(95%CI：1.61~1.99)，1.16(95%CI：1.07~1.27)，1.34(95%CI：1.11~1.61)，1.56(95%CI：1.49~1.64)，1.32 (95%CI：1.23~1.40) and 1.24 (95%CI：1.15~1.33)，respectively. Besides，a non-significant pooled RR of 1.07(95%CI：0.91~1.25) was also estimated for type 2 diabetes and the risk of rectum cancer.［Conclusion］ Type 2 diabetes is associated with an increased risk of digestive system cancer，and might be one of the risk factors for cancers of liver，esophagus，stomach，pancreas，and colon. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |