| 缪亚梅,金 梅.血清人附睾分泌蛋白4检测在卵巢癌诊断中的临床应用[J].中国肿瘤,2013,22(10):838-840. |
| 血清人附睾分泌蛋白4检测在卵巢癌诊断中的临床应用 |
| Clinical Value of Serum Human Epididymial Protein 4 in The Diagnosis of Ovarian Cancer |
| 投稿时间：2013-05-27 |
| DOI：10.11735/j.issn.1004-0242.2013.10.A016 |
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| 中文关键词: 卵巢癌 人附睾分泌蛋白 4 糖类抗原125 |
| 英文关键词:ovarian cancer human epididymal protein 4 carbohydrate antigen 125 tumor marker |
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| 中文摘要: |
| 摘 要：［目的］ 探讨人附睾分泌蛋白 4（human epididymial protein 4，HE4）在卵巢癌诊断中的价值。［方法］ 采用酶联免疫吸附试验和化学发光法检测48例卵巢癌患者、33例卵巢良性肿瘤患者以及38例健康体检者血清HE4以及糖类抗原125（CA125）的水平。［结果］ 血清HE4诊断卵巢癌的ROC曲线下面积为0.921（95%CI：0.887~0.955）。HE4 86.5pmol/L为阈值时诊断敏感度为66.7%，特异性为84.5%。而血清CA125诊断卵巢癌的ROC曲线下面积为0.902（95%CI：0.857~0.947）。CA125 48.2U/ml为阈值时诊断敏感度为62.5%，特异性为81.7%。HE4与CA125联合检测诊断卵巢癌的ROC曲线下面积为0.947(95%CI：0.914~0.980)。卵巢癌Ⅲ~Ⅳ期患者血清HE4水平明显高于Ⅰ~Ⅱ期患者（P<0.001），有淋巴结转移患者血清HE4水平明显高于无淋巴结转移患者（P<0.001）。［结论］ HE4可作为卵巢癌诊断的血清学标志物，且与CA125联合检测可提高卵巢癌诊断效率。 |
| 英文摘要: |
| Abstract：［Purpose］ To evaluate the diagnostic value of human epididymal protein 4 (HE4) for ovarian cancer.［Methods］ Forty-eight cases with ovarian cancer，33 cases with benign ovarian tumor and 38 cases of healthy control were enrolled.Serum HE4 and carbohydrate antigen 125 (CA125) level were detected by enzyme-linked immunosorbent assay and chemiluminescence assay. ［Results］ The area of ROC curve of HE4 for ovarian cancer diagnosis was 0.921（95%CI：0.887~0.955）.The sensitivity was 66.7% and specificity was 84.5% while HE4 cut-off was 86.5pmol/L. The area of ROC curve of CA125 for ovarian cancer diagnosis was 0.902（95%CI：0.857~0.947）.The sensitivity was 62.57% and specificity was 81.7% while CA125 cut-off was 48.2 U/ml.The area of ROC curve of HE4 combined with CA125 for ovarian cancer diagnosis was 0.947(95%CI:0.914~0.980). Serum HE4 level in patients with stage Ⅲ~ Ⅳ or with lymph node metastasis was significantly higher than in stage Ⅰ~Ⅱ or without lymph node metastasis respectively(P<0.05). ［Conclusion］ HE4 might be used as a serum marker in the diagnosis of ovarian cancer. It can improve the efficiency of diagnosis of ovarian cancer when combined with CA125. |
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