| 冯 迪,耿敬姝,于晓宇.Slug、E-cadherin、Vimentin及β-catenin在基底细胞样乳腺癌中的表达[J].中国肿瘤,2013,22(9):757-761. |
| Slug、E-cadherin、Vimentin及β-catenin在基底细胞样乳腺癌中的表达 |
| Expression of Slug，E-cadherin，Vimentin and β-catenin in Basal-like Breast Cancer |
| 投稿时间：2013-07-03 |
| DOI：10.11735/j.issn.1004-0242.2013.09.A018 |
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| 中文关键词: 乳腺癌 Slug 基底细胞样 EMT |
| 英文关键词:breast cancer Slug basal-like EMT |
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| 中文摘要: |
| 摘 要:［目的］ 观察Slug在基底细胞样乳腺癌(BLBC)中的表达情况及其与上皮间质转化(EMT)的关系。［方法］ 依照免疫组化表型筛选出BLBC、管腔A、管腔B/C、Her-2过表达及正常乳腺样型共147例乳腺癌，采用EnVision两步法检测各亚型中Slug、E-cadherin、Vimentin及β-catenin的表达情况。［结果］ 41例BLBC中Slug、Vimentin 阳性率分别为63.4%（26/41）和39.0%(16/41)。E-cadherin表达减弱率为63.4%（26/41）、β-catenin异常表达率为53.7%（21/41）。BLBC组中Slug、Vimentin阳性率高于其他各亚型(P<0.01)。BLBC组中Slug表达与E-cadherin表达减弱和Vimentin表达上调存在相关性（P<0.05）。BLBC组中Slug阳性表达与组织学分级、淋巴结转移相关。［结论］ EMT可能是造成BLBC特殊生物学行为的原因，并且受Slug基因表达的调节。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expression of Slug in basal-like breast carcinoma（BLBC）and its relationship with epithelial-mesenchymal transition(EMT).［Methods］ One hundred and forty-seven cases of breast cancers including BLBC，Luminal A，Luminal B，Her-2 overexpression and normal breast-like were enrolled based on immunophenotypes. The expression of Slug，E-cadherin，Vimentin and β-catenin were detected by immunohistochemistry.［Results］ Slug and Vimentin positive rate in 41 cases of BLBC were 63.4%(26/41) and 39.0%(16/41) respectively. E-cadherin expression weakened in 26 cases(63.4%). β-catenin abnormal expression was observed in 21 cases(53.7%). The positive rates of Slug and Vimentin were higher in BLBC than those in other subtypes of breast cancer(P<0.01). Slug expression significantly related to E-cadherin reduced expression and Vimentin increased expression(P<0.05). Slug positive expression related to grade and lymph node metastasis in BLBC. ［Conclusion］ EMT might be the cause of special biologic behavior in BLBC and be regulated by expression of Slug. |
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