| 陈愉生,王贵清,李鸿茹.Livin和CXCR4蛋白表达与肺癌生物学特征关系的初步探讨[J].中国肿瘤,2013,22(9):748-752. |
| Livin和CXCR4蛋白表达与肺癌生物学特征关系的初步探讨 |
| Expression of Livin and CXCR4 Protein in Lung Cancer Tissue and Their Relationship with Clinicopathological Features |
| 投稿时间：2012-11-13 |
| DOI：10.11735/j.issn.1004-0242.2013.09.A016 |
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| 中文关键词: 凋亡抑制蛋白 Livin CXCR4 肺癌 肿瘤转移 |
| 英文关键词:inhibitor of apoptosis protein Livin CXCR4 lung cancer metastasis |
| 基金项目: |
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| 摘要点击次数: 2250 |
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| 中文摘要: |
| 摘 要：［目的］探讨凋亡抑制蛋白Livin与趋化因子受体CXCR4在肺癌组织与癌旁组织中表达水平及两者的关系。［方法］ 用Western Blot法检测50例肺癌组织及20例对照组中Livin及CXCR4的蛋白表达水平。［结果］ 肺癌组织中Livin蛋白表达阳性率为76%（38/50），显著性高于对照组30%(P＜0.01)；肺癌组织中CXCR4蛋白表达阳性率为88%(44/50)，高于对照组50%（P＜0.01）。Livin和CXCR4蛋白在肺癌组织中的表达与性别、年龄、肿瘤大小、病理类型、分化程度、淋巴结转移及肿瘤分期均无关(P>0.05)。且Livin蛋白表达与CXCR4蛋白表达呈正相关（r=0.552，P＜0.01）。［结论］ Livin蛋白与CXCR4蛋白在肺癌组织呈高表达，两者表达呈正相关，这两种蛋白在肺癌发生、发展中可能存在协同作用。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expression of Livin protein and CXCR4 protein in lung cancer tissues and para-cancerous tissues，and their relationship.［Methods］ Expression of Livin protein and CXCR4 protein was detected by Western Blot assay in 50 cases of lung cancer tissues as well as in 20 cases of the controls. ［Results］ Positive rate of Livin in lung cancer tissues was 76%(38/50)，significantly higher than that in para-cancerous tissues 30%(P＜0.01); positive rate of CXCR4 in lung cancer tissues was 88%(44/50)，higher than that in the control group 50%(P＜0.01). Moreover，expression of Livin and CXCR4 did not correlate to gender，age，tumor size，histologic type，grade，lymph node metastasis and clinical staging in lung cancer tissues(P＞0.05). Positive correlation between the expression of Livin and CXCR4 was found(r=0.552，P<0.01).［Conclusion］ Livin and CXCR4 are highly expressed in lung cancer tissues. The expressions of Livin show positive associated with CXCR4，and play synergistic effect in carcinogenss and progress in lung cancer. |
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