| 中文关键词: menin蛋白 MEN1 生物学功能 |
| 英文关键词:Menin protein MEN1 biological function |
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| 中文摘要: |
| 摘 要：Menin蛋白是MEN1基因的表达产物，MEN1是多发性内分泌肿瘤1型综合征（multiple endocrine neoplasia type1，MEN1）的关键致病基因之一。menin在细胞核中与其他关键转录因子相互作用，直接参与组蛋白甲基化修饰等基因表达调控过程。此外，menin在基因组稳定、细胞分裂增殖及细胞周期调控中都发挥着重要的作用，在肿瘤的发生和发展中扮演着重要的角色。全文对menin蛋白的生物学功能进展进行综述。 |
| 英文摘要: |
| Abstract:Menin is a protein encoded by the gene multiple endocrine neolpasia type 1(MEN1)，which is the predominant cause for hereditary MEN1 syndrome. Menin plays various biological roles: Menin interact with other key transcription factor in the nucleus，directly involved in histone methylation and gene expression regulation process. In addition，menin plays an important role in genome stability，cell proliferation and cell cycle regulation.It is closely related to carcinogenesis and develope of the tumor. This paper reviews the progress of biological function of Menin protein. |
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