| 宋晓征,李成杰,张紫寅.应用替莫唑胺治疗63例视神经胶质瘤的疗效观察[J].中国肿瘤,2013,22(6):473-476. |
| 应用替莫唑胺治疗63例视神经胶质瘤的疗效观察 |
| Clinical Efficacy of Temozolomide in 63 Cases with Optic Pathway Gliomas |
| 投稿时间：2013-01-26 |
| DOI：10.11735/j.issn.1004-0242.2013.06.A201302066 |
|
 |
| 中文关键词: 替莫唑胺 视神经胶质瘤 化疗 |
| 英文关键词:temozolomide optic pathway gliomas chemotherapy |
| 基金项目: |
|
| 摘要点击次数: 2718 |
| 全文下载次数: 1583 |
| 中文摘要: |
| 摘 要: ［目的］ 观察视神经胶质瘤(optic pathway glioma，OPG)术后联合替莫唑胺(temozolomide，TMZ)的治疗效果。［方法］ 收集2007年6月至2011年9月收治的75例经术后病理检查确诊为视神经胶质瘤患者的临床资料。63例患者(治疗组)在外科手术治疗后给予替莫唑胺化疗，对照组12例患者未服用替莫唑胺。随访6～24个月。［结果］ 替莫唑胺化疗的有效率为84.1％，患者平均肿瘤无进展生存时间为11.4±4.5个月。TMZ治疗组无一例肿瘤患者复发，而对照组2例视神经胶质瘤复发，治疗组肿瘤复发率明显低于对照组（χ2=5.34，P<0.05）。两组患者脑水肿发生率无明显差异。［结论］ 视神经胶质瘤患者术后联合替莫唑胺化疗效果明显，可延长患者的生存时间，降低肿瘤的复发率。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the clinical effect of surgery combined with temozolomide (TMZ) chemotherapy for optic pathway gliomas(OPG).［Methods］ The data of 75 patients pathologicaly proved OPG from June 2007 to September 2011 were enrolled in this study. After the surgical treatment，63 cases were treated with temozolomide based on body surface area，and 12 cases without temozolomide as control group. All were followed up for 6~24 months. ［Results］ The clinical response rate of temozolomide chemotherapy was 84.1%，the mean tumor progression-free survival was 11.4±4.5 months. In the follow-up time，no patient in temozolomide group was recurrent，while 2 cases of glioma recurrence were observed in control group. There was lower glioma recurrence rate in temozolomide group than that in control group(χ2=5.34，P<0.05). There was no significant difference of rate of cerebral edema between two groups.［Conclusion］ Postoperative combined with temozolomide may prolong the survival，and reduce the recurrence in patient with optic pathway gliomas. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|