| 姚春筱,张树平,陈保民.调强适形放疗联合替莫唑胺治疗恶性脑胶质瘤的临床观察[J].中国肿瘤,2013,22(3):238-240. |
| 调强适形放疗联合替莫唑胺治疗恶性脑胶质瘤的临床观察 |
| Clinical Effect of Intensity Modulated Radiation Therapy Combined with Concomitant and Adjuvant Temozolomide in the Treatment for Malignant Glioma |
| 投稿时间：2013-01-09 |
| DOI：10.11735/j.issn.1004-0242.2013.03.A201301010 |
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| 中文关键词: 恶性胶质瘤 调强适形放疗 替莫唑胺 |
| 英文关键词:malignant glioma intensity modulated radiation therapy temozolomide |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 观察调强适形放疗(IMRT)联合替莫唑胺(TMZ)治疗恶性脑胶质瘤的临床疗效。［方法］ 28例术后病理诊断为高级别胶质瘤（WHO Ⅲ~Ⅳ）的患者，术后放射治疗为全脑左、右对穿野常规照射（WBRT）并后程调强加量照射。常规放射治疗剂量为40Gy/20f/4w，调强放射治疗剂量为20Gy/4f/2w；放疗同步口服替莫唑胺(TMZ) 治疗6个周期，之后再接受至少2个周期的常规TMZ治疗。［结果］ 中位生存时间及无进展生存时间分别为11.5个月和7.2个月；1年总生存率为53.57%，2年总生存率为25.00%。常见的不良反应为恶心、呕吐，血液学毒性是白细胞和血小板下降，但仅限于Ⅰ～Ⅱ度。［结论］ IMRT同步TMZ治疗恶性脑胶质瘤，安全有效，不良反应轻微。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate clinical efficacy of intensity modulated radiation therapy (IMRT) combined with concomitant and adjuvant temozolomide(TMZ) in the treatment for malignant glioma.［Methods］ A total of 28 malignant glioma cases (grade Ⅲ～Ⅳ) pathologically proved were enrolled.After 40Gy/20f/4w by conventional fractionation irradiation delivered through whole brain left/right fields，IMRT was started as a boost.The irradiation dose of dose-escalation was 20Gy/4f/2w; TMZ was given for 6 cycles at the same time，then at least 2 cycles by the routine treatment.［Results］ The median survival time and the progression free survival time were 11.5 months and 7.2 months respectively.1- year and 2- year survival rate were 53.57％ and 25.00％ respectively.The common side effects were nausea，vomiting; hematologic toxicity was white cells and platelets decreased(degreeⅠ～Ⅱ).［Conclusion］ IMRT plus concomitant and adjuvant TMZ for malignant glioma is safe and effective，with mild adverse reactions. |
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