| 王 徽,孙志强,张北光.介入热灌注化疗栓塞对肝癌患者血管内皮生长因子的影响[J].中国肿瘤,2012,21(12):944-946. |
| 介入热灌注化疗栓塞对肝癌患者血管内皮生长因子的影响 |
| Effect of Interventional Hyperthermia Chemoembolization on Serum Vascular Endothelial Growth Factor in Patients with Hepatocellular Carcinoma |
| 投稿时间：2012-11-27 |
| DOI： |
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| 中文关键词: 肝肿瘤 介入性热化疗 栓塞 血管内皮生长因子 |
| 英文关键词:hepatocellular carcinoma interventional heated chemotherapy embolization vascular endothelial growth factor |
| 基金项目:长春市科技局项目（编号：08SF24） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨介入热灌注化疗栓塞对肝癌患者血管内皮生长因子（VEGF）的影响。［方法］ 采用ELISA方法检测60例原发性肝癌患者（介入热疗组30例和常规介入组30例）治疗前后VEGF的变化，并对两组数据进行对比分析。［结果］ 治疗前介入热疗组血清VEGF中位值为256.42pg/ml，常规介入组为255.16pg/ml；治疗后1周介入热疗组为179.37pg/ml，较前下降；常规介入组343.58pg/ml，较治疗前升高，两组比较均有显著性差异（P<0.05）。介入热疗组2年生存率（70%）明显高于常规介入组（50%）。［结论］ 介入热灌注化疗栓塞可抑制VEGF的产生，对减少肿瘤新生血管的形成、防止或降低肿瘤的复发起到积极的作用，其疗效优于常规介入疗法，是治疗中晚期肝癌的一种安全有效的方法。 |
| 英文摘要: |
| Abstract: ［Purpose］ To observe the effect of interventional hyperthermia chemoembolization(IHCE) on serum vascular endothelial growth factor(VEGF) in patients with hepatocellular carcinoma. ［Methods］ A total of 60 cases with primary hepatocellular carcinoma were divided into two groups: IHCE group (30 cases) and conventional intervention chemoembolization (ICE) group (30 cases). The levels of VEGF were examined by ELISA method. ［Results］Before treatment the median of VEGF was 256.42 pg/ml in IHCE group，while one week after treatment it was 179.37 pg/ml，with significant difference(P<0.05). Before treatment the median of VEGF was 255.16 pg/ml in ICE group，while one week after treatment it was 343.58 pg/ml，with significant difference(P<0.05). The 2?鄄year survival rate in IHCE group(70%) was higher than that in ICE group(50%)(P<0.05). ［Conclusion］ IHCE inhibits producting VEGF，which plays a positive role in reducing the formation of vascular growth of neoplasm and preventing or reducing the recurrence of neoplasm. It is a safe and effective method in the treatment for advanced hepatocellular carcinoma. |
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