Abstract: ［Purpose］ To investigate the prognosis of locoregionally advanced nasopharyngeal carcinoma treated with intensity-modulated radiotherapy(IMRT) and platinum-based chemotherapy. ［Methods］ One hundred eighty-one patients with locally advanced nasopharyngeal carcinoma were retrospectively divided into three subgroups: locally advanced (T3~4N0~1M0) group(n=66)，regionally advanced (T1~2N2~3M0)group (n=42) and the mixed group(T3~4N2~3M0)(n=73). The patients were all treated with definitive intensity-modulated radiotherapy and platinum-based chemotherapy with median follow-up of 24 months.［Results］ The 2-year locoregional control(LRC) rate for locally advanced group，regionally advanced group，and the mixed type group was 92.3%，100% and 97.2% respectively(P=0.32)，the 2-year distant metastasis free survival(DMFS) rate was 91.1%，78.2% and 76.3% repectively(P=0.016)，the 2-year progress free survival(PFS) rate was 86.7%，78.2% and 77.0% respectively(P=0.095). Cox multivariates analysis showed that N stage was the only independent risk factor for distant metastasis and disease-specific death. ［Conclusions］ Based on IMRT and platinum-based chemotherapy，locoregionally advanced cases with N2~3 have a poor prognosis with a higher rates of distant metastasis and disease related death.
