| 王耀辉,曲卓慧,秦 英.TS、ERCC1和DNA-PKcs在大肠癌组织中的表达及临床意义[J].中国肿瘤,2012,21(10):794-798. |
| TS、ERCC1和DNA-PKcs在大肠癌组织中的表达及临床意义 |
| Expression of TS, ERCC1 and DNA-PKcs in Colorectal Carcinoma and its Clinical Significance |
| 投稿时间：2012-03-01 |
| DOI： |
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| 中文关键词: 大肠癌 胸苷酸合酶 切除修复交叉互补基因-1 DNA-依赖蛋白激酶 |
| 英文关键词:colorectal carcinoma thymidylate synthase excision repair cross-complementing-1 DNA-dependent protein kinase |
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| 中文摘要: |
| 摘 要：［目的］ 探讨TS、ERCC1和DNA-PKcs在大肠癌组织中的表达及其临床意义。［方法］ 将133例大肠癌标本与17例正常大肠组织标本构建成组织芯片，应用免疫组化SP法检测TS、ERCC1和DNA-PKcs在大肠癌芯片中的表达，并分析其与大肠癌临床病理特征的关系。［结果］ TS在大肠癌组织中的表达显著高于正常大肠组织（P<0.05），而ERCC1、DNA-PKcs在大肠癌组织中的表达与正常大肠组织无明显差异（P>0.05）。TS、ERCC1和DNA-PKcs的表达均与淋巴结转移和Dukes分期有关（P<0.05）。ERCC1和DNA-PKcs、TS和ERCC1表达间均呈明显正相关（P<0.01）。［结论］ 检测TS、ERCC1和DNA-PKcs在大肠癌中的表达对预测大肠癌的发生、发展有一定意义。 |
| 英文摘要: |
| Abstract:［Purpose］ To investigate the expression of thymidylate synthase(TS)， excision repair cross-complementing-1（ERCC1）and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in colorectal carcinoma and its clinical significance． ［Methods］ A tissue microarray was constructed from 133 cases colorectal carcinoma and 17 cases with normal colorectal specimens, and the expression of TS,ERCC1 and DNA-PKcs were examined by immunohistochemistry SP method. The relationship of their expression with clinicopathological features of colorectal carcinoma was analyzed. ［Results］ The positive rate of TS in colorectal carcinoma was significantly higher than that in normal colorectal tissues(P<0.05), while the positive rate of ERCC1 and DNA-PKcs in colorectal carcinoma were all similar to those in normal colorectal tissues (P>0.05). The expressions of TS,ERCC1 and DNA-PKcs in colorectal carcinoma were all related to lymph node metastasis and Dukes staging(P<0.05). There was a positive relationship between the expression of ERCC1 and DNA-PKcs as well as TS and ERCC1（P<0.05）.［Conclusion］ Detecting the expression of TS, ERCC1 and DNA-PKcs in colorectum might predict the prognosis of colorectal carcinoma. |
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