| 郭 红,王天禄,于 洪.增强CT定位对非小细胞肺癌三维适形放疗计划参数的影响[J].中国肿瘤,2012,21(9):695-698. |
| 增强CT定位对非小细胞肺癌三维适形放疗计划参数的影响 |
| The Effect of Contrast-Enhanced CT on 3D-CRT Treatment Planning Parameters in Patients with Non-small Cell Lung Cancer |
| 投稿时间：2012-06-12 |
| DOI： |
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| 中文关键词: 非小细胞肺癌 放射疗法 增强CT 平扫CT |
| 英文关键词:NSCLC radiotherapy contrast-enhanced CT plain CT |
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| 中文摘要: |
| 摘 要：［目的］ 观察非小细胞肺癌（NSCLC）三维适形放疗（3D-CRT)中增强CT定位对放疗计划参数的影响。［方法］ 对97例在CT定位下拟行根治性3D-CRT的NSCLC患者，分别以CT平扫图像、增强CT图像勾画大体肿瘤靶区（GTVCT和GTVCT+），分别制定放疗计划。［结果］增强CT明显改变35例(36.1％)患者PTV和/或GTV。增强CT组与平扫CT组的计划参数GTV的体积（VGTV）、受照射量≥45Gy的食管占全食管体积的比例（VE45）和脊髓最大受照射剂量（SCM）差异有统计学意义（P均＜0.001）。［结论］ 利用增强CT定位能更加准确地确定靶区，据此制定3D-CRT可更优的覆盖靶区，降低脊髓、食管的受照射剂量。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the effect of contrast-enhanced CT and on the three-dimensional conformal radiotherapy(3D-CRT) treatment planning parameters in patients with non-small cell lung cancer (NSCLC). ［Methods］ Contrast-enhanced CT was performed in 97 pathologically proven NSCLC patients for radical radiotherapy. The gross tumor volume(GTV) was initially delineated on the CT images (GTVCT)，and the corresponding contrast-enhanced，CT data were subsequently used to delineate the target volume(GTVCT+).3D-CRT plans were made according to different target volume. ［Results］ Contrast-enhanced CT clearly altered the radiation therapy volume (PTV/GTV) in 35 patients (36.1%). Between the contrast-enhanced CT and plain CT radiotherapy planning，differences of indexes including volume of GTV (VGTV)，esophageal volume receiving at least 45Gy (VE45)，the maximum dose of spinal cord receiving(SCM) were all with statistically significant（P all<0.001）.［Conclusions］ The volume is more accurately determined by contrast-enhanced CT. 3D-CRT treatment planning accord to contrast-enhanced CT may coverage the target better，and reduce the dose of spinal cord and esophageal. |
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