| 戴 敏,赵迎春.低级别、高级别卵巢浆液性癌临床病理分析及CA125、p53和Ki-67表达的意义[J].中国肿瘤,2012,21(8):631-634. |
| 低级别、高级别卵巢浆液性癌临床病理分析及CA125、p53和Ki-67表达的意义 |
| Clinicopathologic Analysis of Low- and High-grade Ovarian Serous Carcinomas and Significance of CA125， p53 and Ki-67 Expression |
| 投稿时间：2012-03-20 |
| DOI： |
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| 中文关键词: 卵巢浆液性癌 p53 Ki-67 CA125 免疫组织化学 |
| 英文关键词:ovarian serous carcinomas p53 Ki-67 CA125 immunohistochemistry |
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| 中文摘要: |
| 摘 要: ［目的］ 探讨低、高级别卵巢浆液性癌中CA125、p53和Ki-67的表达及其与预后的相关性。［方法］ 依照两级分级系统对卵巢浆液性癌进行分级，分别选取低级别浆液性癌31例和高级别癌31例，观察其临床病理特点，并采用免疫组织化学SP法检测癌组织中CA125、p53和Ki-67的表达情况。［结果］ 低级别组p53阳性率显著低于高级别组(32.26％ vs 74.19％，P<0.001)，Ki-67阳性指数显著低于高级别组(29.03％ vs 80.65％，P<0.001)； 低级别组5年总生存率、无病生存率均优于高级别组(P<0．05)。［结论］ 两级分级系统对卵巢浆液性癌的预后判断具有提示意义，CA125、p53和Ki-67在卵巢低、高级别浆液性癌中的表达差异有统计学意义。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expression of CA125， p53，Ki-67 protein and their prognostic values for low- and high-grade ovarian serous carcinomas. ［Methods］ A total of 31 cases of low-grade and 31 cases of high-grade ovarian serous carcinomas were selected based on the two-tier grading system. Immunohistochemistry was used to detect CA125， p53 and Ki-67 protein expression in all cases. Correlation of the two-tier system with immunohistochemical results and prognostic parameters were performed. ［Results］ Significant differences in protein expressions were found between the low- and high-grade serous carcinomas. The high-grade serous carcinomas had a significantly higher expression level of p53 (32.26％ vs 74.19％， P<0.001) and Ki-67 (29.03％ vs 80.65％，P<0.001). The overall survival， disease-free survival and 5-year survival rates were significantly higher in the low-grade serous carcinoma cases than those in the high-grade cases （P<0.05）. ［Conclusions］ The two-tier system for grading ovarian serous carcinomas shows a good predicting value for prognosis. There are significantly differences in expressions of CA125， p53 and Ki-67 between low- and high-grade ovarian serous carcinomas. |
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