| 王 译,黎 功,杨远游.伽玛刀治疗22例小肝癌疗效分析[J].中国肿瘤,2012,21(8):627-630. |
| 伽玛刀治疗22例小肝癌疗效分析 |
| Effect of γ-Knife in the Treatment for 22 Cases with Small Hepatocellular Carcinoma |
| 投稿时间：2011-12-16 |
| DOI： |
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| 中文关键词: 肝肿瘤 立体定向放射治疗 伽玛刀 疗效 |
| 英文关键词:hepatocellular carcinoma stereotactic radiation therapy γ-knife efficacy |
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| 中文摘要: |
| 摘 要：［目的］ 评价伽玛刀对原发性小肝癌的治疗疗效。［方法］ 2005年1月至 2007年10月期间，无法行手术切除或拒绝手术切除的原发性小肝癌22例患者采用伽玛刀治疗。50%～70%等剂量曲线包绕PTV，（36～50）Gy/（8～12）f，（4～5）Gy/f，5f/w，平均照射剂量43.5Gy。用Kaplan-Meier分析生存率。［结果］ CR 4例（18.18%），PR 12例（54.55%），SD 4例（18.18%），PD 2例（9.09%），总有效率为72.73%（16/22）。1、2、3年生存率分别为81.2%、68.7%和62.4%。中位生存时间40.0个月。治疗副反应轻微，无严重放射性肝损伤发生。［结论］ 伽玛刀对原发性小肝癌患者的治疗安全、有效，毒副反应较小，放射反应可耐受。 |
| 英文摘要: |
| Abstract:［Purpose］ To evaluate the efficacy of γ-knife for small hepatocellular carcinoma(SHCC). ［Methods］ During Jan 2005 to Oct 2007，22 cases with SHCC which were inoperable or refusing to surgical treatment were included and treated by γ-knife radiotherapy. Patients were treated with (36~50) Gy/ (8~12) f，(4~5)Gy/f，5f/w，prescribed to the PTV-encl. (50%~70%)-isodose. The cumulative survival rates were analyzed by Kaplan-Meier method. ［Results］ CR was attained in 4 cases(18.18%)；PR， 12 (54.55%)；NC， 4 (18.18%) and PD，2 (9.09%).Overall response rate was 72.73%(16/22). The 1-，2- and 3-year survival was 81.2%，68.7% and 62.4% respectively. The median survival time was 40.0 months. The treatment toxicity was mild and there was no serious radiation liver injury. ［Conclusion］ γ-knife for SHCC is safe，feasible，low toxicity and to be tolerated. |
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