| 邓立力,赵玉莹,姜秋颖.STAT3和p38MAPK在胃癌中的表达及临床意义[J].中国肿瘤,2012,21(5):383-386. |
| STAT3和p38MAPK在胃癌中的表达及临床意义 |
| The Expression of STAT3 and p38MAPK in Gastric Cancer and its Clinical Significance |
| 投稿时间：2012-01-30 |
| DOI： |
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| 中文关键词: 胃癌 STAT3 p38MAPK 免疫组化 |
| 英文关键词:gastric cancer STAT3 p38MAPK |
| 基金项目:哈尔滨医科大学附属第二医院青年基金（QN2006-20） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨STAT3和p38MAPK在胃癌中的表达及临床意义。［方法］ 采用免疫组化法检测80例胃癌组织及40例癌旁组织中STAT3和p38MAPK的表达。［结果］ 80例胃癌组织中STAT3的阳性表达率为72.5%，明显高于癌旁组织的17.5% (P<0.001)；STAT3的表达与胃癌患者性别、年龄、浸润深度无关（P＞0.05），而与分化程度、淋巴结转移、TNM分期、远处转移有关 (P<0.001)。80 例胃癌组织中p38MAPK 的阳性表达率为71.3%，明显高于癌旁组织的12.5%(P<0.05)；p38MAPK的表达与胃癌患者性别、年龄、淋巴结转移无关（P＞0.05），而与分化程度、浸润深度、TNM分期、远处转移有关(P<0.001)。胃癌中STAT3和p38MAPK的表达呈正相关（r=0.6986，P＜0.01）。［结论］ 胃癌中STAT3和p38MAPK均过表达，可能与胃癌的发生发展有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of STAT3 and p38MAPK in gastric cancer and its clinical significance. ［Methods］ The expression of STAT3 and p38MAPK in tissue samples from 80 cases with gastric cancer and 40 cases with cancer adjacent tissues were detected by immunohistochemical method. ［Results］ The positive rate of STAT3 in 80 cases with gastric cancer tissue was significantly higher than that in cancer adjacent tissues (72.5% vs 17.5%，P＜0.001). The expression of STAT3 in gastric cancer did not relate to age，gender and invasive depth(P＞0.05)，but relate to differentiation，TNM staging，lymph node metastasis and distant metastasis (P<0.001). The positive rate of p38MAPK in 80 cases with gastric cancer was significantly higher than that in cancer adjacent tissues (71.3% vs 12.5%，P<0.05). The expression of p38MAPK in gastric cancer did not relate to age，gender and lymph node metastasis (P＞0.05)，but relate to differentiation，invasive depth，TNM staging and distant metastasis (P<0.001).There was a positive correlation between STAT3 and p38MAPK expression(r=0.6986，P＜0.01). ［Conclusion］ Over expression of STAT3 and p38MAPK might be correlated to carcinogenesis in gastric cancer. |
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