| 刘 宏,叶玉坤,李桂梅.TTF-1临床检测诊断pN0期肺腺癌淋巴结微转移[J].中国肿瘤,2012,21(4):303-305. |
| TTF-1临床检测诊断pN0期肺腺癌淋巴结微转移 |
| Detection of TTF-1 for Diagnosis of Lymph Node Micrometastasis at pN0 Stage of Lung Adenocarcinoma |
| 投稿时间：2012-02-22 |
| DOI： |
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| 中文关键词: 肺腺癌 淋巴结微转移 甲状腺转录因子-1 免疫组化 |
| 英文关键词:lung adenocarcinoma lymph node micrometastasis thyroid transcription factor-1 immunohistochemistry |
| 基金项目:南京军区医药卫生重点项目（07Z011) |
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| 中文摘要: |
| 摘 要：［目的］探讨检测甲状腺转录因子-1（TTF-1）对肺腺癌淋巴结微转移的诊断价值。［方法］ 选取54例术后常规HE诊断为N0期，且肿瘤原发灶TTF-1表达阳性的肺腺癌病例，采用免疫组化法检测TTF-1在54例患者共893枚淋巴结中的表达。选取同期明确淋巴结转移且原发灶TTF-1表达阳性的肺腺癌病例作为阳性对照，5例肺良性病变术中所取5枚肺内或纵隔淋巴结作为阴性对照。［结果］ 54例患者893枚淋巴结中检测出9例共21枚淋巴结阳性，阳性淋巴结检出率2.4%（21/893），微转移病例检出率16.7%（9/54）。TTF-1在阳性对照组淋巴结中均表达，在阴性对照组中无表达。 ［结论］ 采用免疫组化法检测淋巴结中TTF-1表达，可以发现并诊断肺腺癌淋巴结微转移。 |
| 英文摘要: |
| Abstract: ［Purpose］To investigate the diagnostic value of detection of thyroid transcription factor-1(TTF-1) for lymph node micrometastasis in lung adenocarcinomas.［Methods］ Fifty-four pN0 stage (node negative according to histologic examination) lung adenocarcinoma patients with positive expression of TTF-1 in primary lung adenocarcinoma niduses were involved in this study. The TTF-1 expression in 893 lymph nodes from the patients were detected by immunohistochemical method. The metastasis lymph nodes from lung adenocarcinoma patients with the positive expression of TTF-1 in primary niduses were selected as positive control, 5 lymph nodes from 5 patients of lung benign lesion were selected as negative control.［Results］Among 893 lymph node samples from 54 patients, 21 lymph node samples from 9 patients was found positive. The rate of positive lymph node was 2.4%. The rate of the patients with micrometastasis in lymph node was 16.7%. TTF-1 expressed in all of lymph nodes of the postive control group, none of lymph node showed TTF-1 expression in negative control group. ［Conclusion］The immunohistochemistry assay of TTF-1 is a potential method for the diagnosis of micrometastasis in lymph node of lung adenocarcinoma patients. |
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