| 顾 勇,杨 艳,段 炜.RhoA在胃癌细胞核中的表达及预后意义[J].中国肿瘤,2012,21(3):230-233. |
| RhoA在胃癌细胞核中的表达及预后意义 |
| Expression and Prognostic Significance of RhoA in Gastric Cancer Cell Nucleus |
| 投稿时间：2011-11-07 |
| DOI： |
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| 中文关键词: RhoA 胃癌 预后 免疫组织化学 |
| 英文关键词:RhoA gastric cancer prognosis immunohistochemistry |
| 基金项目: |
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| 摘要点击次数: 1763 |
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| 中文摘要: |
| 摘 要: ［目的］ 探讨RhoA蛋白在胃癌细胞核中的表达及预后意义。［方法］ 选取有详细临床资料的胃癌组织179例及正常胃黏膜组织80例，应用免疫组织化学改良二步法检测RhoA蛋白的胞核表达。［结果］ RhoA蛋白在胃癌及正常胃黏膜组织细胞核中的表达阳性率分别为69.8％(125/179)和25.0％（20/80），差异有显著性(P<0.05)。RhoA蛋白胞核表达率与胃癌肿瘤分化、TNM分期、淋巴结转移有关（P<0.05）。RhoA胞核阳性患者的术后生存期短于阴性患者(P=0.022)。Cox风险比例模型表明，RhoA胞核阳性是胃癌术后预后的独立指标（OR=3.09，P=0.005）。［结论］ RhoA 蛋白在胃癌细胞核中过表达，是判断胃癌患者术后生存期的独立预后指标。 |
| 英文摘要: |
| Abstract: ［Purpose］ To investigate the expression of RhoA in gastric cancer cell nucleus and its prognostic significance. ［Methods］ One hundred and seventy-night gastric cancer tissues and 80 normal gastric tissues with detailed clinical information were enrolled. The expression of RhoA in cell nucleus was detected by Immunohistochemistry (modified two-step method). ［Results］ The positive rate of RhoA in gastric cancer and normal mucosa cell nucleus was 69.8% (125/179) and 25.0%（20/80）respectively，with significantly difference (P<0.05). The expression of RhoA in gastric cancer cell nucleus was related to differentiation， TNM stage and lymph node metastasis (all P <0.05). The postoperative survival time in gastric cancer patients with positive RhoA expression was significantly shorter than that in patients with negative RhoA expression (P=0.022).Cox proportional hazards model revealed that RhoA expression was an independent prognostic factor in patients with gastric cancer (OR=3.09，P=0.005).［Conclusion］ RhoA is over expression in gastric cancer cell nucleus， RhoA could serve as an independent prognostic biomarker to evaluate postoperative survival in patients with gastric cancer. |
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