| 王晓曈,李 杰,刘 瑞.非小细胞肺癌患者血清CA125水平与疾病进展时间的相关性[J].中国肿瘤,2012,21(2):150-152. |
| 非小细胞肺癌患者血清CA125水平与疾病进展时间的相关性 |
| Correlation Between Serum CA125 and Time to Progression(TTP) in Patient with Non-small Cell Lung Caner |
| 投稿时间：2011-08-01 |
| DOI： |
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| 中文关键词: 非小细胞肺癌 糖类抗原125 疾病进展时间 预后 |
| 英文关键词:non-small cell lung cancer CA125 time to progression prognosis |
| 基金项目:国家自然科学基金（81072802） |
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| 摘要点击次数: 1780 |
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| 中文摘要: |
| 摘 要：［目的］评价非小细胞肺癌（NSCLC）患者血清糖类抗原（CA125）水平与疾病进展时间（TTP）的关系。［方法］对中国中医科学院广安门医院2006年10月～2009年10月收治的154例非小细胞肺癌患者的血清CA125水平与疾病进展时间的相关性进行回顾性研究。［结果］血清CA125水平与临床分期相关，Ⅳ期患者血清CA125水平明显高于ⅢB期（P＜0.05）。血清CA125水平≥123U/ml的患者半年内进展的风险比CA125水平＜123U/ml的患者增加89%（OR=1.889,95%CI：1.254~2.845，P=0.002）。［结论］ 血清CA125水平与患者疾病进展时间有明显的相关性，可通过检测CA125水平判断患者预后。 |
| 英文摘要: |
| Abstract: ［Purpose］To analyze the correlation between serum CA125 and time to progression (TTP) in the patients with non-small cell lung cancer (NSCLC). ［Methods］ Retrospective study on the correlation between serum CA125 and TTP was conducted in 154 NSCLC cases from Guang’anmen Hospital, China Academy of Chinese Medical Science. ［Results］ The level of serum CA125 in patients with stage Ⅳ was significantly higher than that in those with stageⅢB （P＜0.05）. In term of tumour progress risk in 6 months, the patients with a high level of serum CA125 (≥123U/ml) had 89% higher risk than patients with a low level of serum CA125 (<123U/ml) (P=0.002). ［Conclusion］ There is obvious correlation between the serum level of CA125 and TTP in patients with NSCLC. The serum level of CA125 is a helpful prognostic index, which is especially valuable to evaluate prognosis and to establish the clinical therapeutic project. |
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