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| 1975-2024年启东市胃癌死亡率及潜在寿命损失分析 |
| Analysis of Gastric Cancer Mortality and Years of Potential Life Lost in Qidong City, 1975–2024 |
| 投稿时间：2026-07-02 修订日期：2026-08-25 |
| DOI： |
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| 中文关键词: 胃癌 死亡率；潜在寿命损失；趋势分析 |
| 英文关键词:gastric cancer mortality rate potential years of life lost trend analysis |
| 基金项目:南通大学临床医学专项课题 |
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| 摘要点击次数: 38 |
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| 中文摘要: |
| 摘要:[目的] 研究分析1975-2024年江苏省启东市居民胃癌死亡的变化趋势和对潜在寿命损失的影响，为制定相关防治政策提供理论依据。[方法] 根据1975-2024年启东市肿瘤登记资料，对居民胃癌死亡率和潜在寿命损失指标进行分析，计算粗死亡率（crude rate, CR）、中国人口标化死亡率（age-standardized mortality rate by Chinese standard population，ASMRC）、潜在减寿年数（potential years of life lost, PYLL）、标化潜在减寿年数（Standardized potential years of life lost，SPYLL）、平均减寿年数（Average Years of Life Lost, AYLL）、标化平均减寿年数（Standardized Average Years of Life Lost, SAYLL）、潜在减寿年数率（potential years of life lost rate, PYLLR）、标化潜在减寿年数率（Standardized potential years of life lost rate，SPYLLR）等，采用Joinpoint 5.1.0软件对上述指标进行趋势分析。[结果] 1975-2024年启东市居民胃癌死亡16 998例，其中男性10 900例，女性6 098例；CR为30.26/10万，其中男性为39.37/10万，女性为21.41/10万；ASMRC为17.46/10万，其中男性为22.84/10万，女性为12.30/10万；CR的AAPC为0.13%( P=0.762)，其中男性为0.18%( P=0.701)，女性为0.03%( P=0.966)，趋势均无统计学意义；ASMRC均呈现下降趋势，AAPC=-2.71%，男性AAPC=-2.90%，女性AAPC=-2.58%（均P<0.001)；SPYLL为78 374.32人年，其中男性47 302.31人年，女性31 036.15人年；SAYLL为9.38年/人，其中男性8.38年/人，女性11.46年/人；SPYLLR为1.54‰，其中男性1.87‰，女性1.22‰。SPYLL、SAYLL和SPYLLR的的AAPC分别为-3.31%、-2.12%和-3.03%，男女性SPYLL的AAPC分别为-3.64%和-2.92%；SAYLL的AAPC分别为-2.48%和-1.67%；SPYLLR的AAPC分别为-3.37%和-2.64%（均P<0.001)。各年龄组CR随着年龄升高而升高，且各年龄组CR和PYLLR均存在明显下降趋势。50-59岁组CR和PYLLR降低速度最快，其次是30-39岁组，80+岁组CR降低速度最慢。 [结论] 50年来启东市居民胃癌粗死亡率无明显变化，标化后的死亡率及潜在寿命损失相关指标均呈现下降趋势，但总体负担仍然较重，尤其是男性和高年龄组的死亡率和潜在减寿损失率较高，应给予更多干预措施。 |
| 英文摘要: |
| Abstract:[Purpose]To investigate and analyze the temporal trends of gastric cancer mortality and its impact on potential years of life lost among residents in Qidong City, Jiangsu Province from 1975 to 2024, so as to provide a theoretical basis for the formulation of relevant prevention and control strategies.[Methods]Based on the population-based cancer registry data of Qidong City covering 1975–2024, indicators related to gastric cancer mortality and premature life loss were calculated, including crude rate (CR), age-standardized mortality rate by Chinese standard population (ASMRC), potential years of life lost (PYLL), standardized potential years of life lost (SPYLL), average years of life lost (AYLL), standardized average years of life lost (SAYLL), potential years of life lost rate (PYLLR), and standardized potential years of life lost rate (SPYLLR). Joinpoint 5.1.0 software was adopted to conduct trend analyses for all the above indicators.[Results]A total of 16,998 gastric cancer deaths were recorded in Qidong City during 1975–2024, consisting of 10,900 males and 6,098 females. The overall CR was 30.26/105, with 39.37/105 for males and 21.41/105for females. The overall ASMRC was 17.46/105,with 22.84/105 in males and 12.30/105in females. The average annual percent change (AAPC) of overall CR was 0.13% (P=0.762), with an AAPC of 0.18% (P=0.701) for males and 0.03% (P=0.966) for females; none of these trends reached statistical significance. By contrast, ASMRC showed a consistent declining trend across genders: the overall AAPC was ?2.71%, ?2.90% for males and ?2.58% for females (all P<0.001).The total SPYLL was 78,374.32 person-years, with 47,302.31 person-years for males and 31,036.15 person-years for females. The overall SAYLL was 9.38 years/person, with 8.38 years/person for male and 11.46 years/person for female. The overall SPYLLR was 1.54‰, with 1.87‰ for males and 1.22 ‰ for females.The AAPC values of SPYLL, SAYLL and SPYLLR for the whole population were ?3.31%, ?2.12% and ?3.03%. Stratified by gender, the AAPCs of SPYLL were ?3.64% (males) and ?2.92% (females); the AAPCs of SAYLL were ?2.48% (males) and ?1.67% (females); the AAPCs of SPYLLR were ?3.37% (males) and ?2.64% (females) (all P<0.001).Age-specific CR increased with advancing age, and both age-specific CR and PYLLR exhibited prominent descending trends across all age groups. The 50–59 years group witnessed the fastest declines in CR and PYLLR, followed by the 30–39 years group, whereas the ≥80 years group had the slowest reduction in CR.
[Conclusions]Over the past 50 years, the CR of gastric cancer among Qidong residents remained stable without significant fluctuation, while ASMRC and all indicators of premature life loss showed decreasing trends. The overall disease burden of gastric cancer remains substantial, with particularly high mortality and premature life loss rates observed in males and the elderly population. Targeted and intensified intervention strategies should be prioritized for these high-risk subgroups. |
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