| Purpose To analyze the incidence, mortality, and temporal trends of nasopharyngeal carcinoma in Guangxi cancer registration areas in 2022 and from 2018 to 2022.
Methods Data from Guangxi cancer registries included in the China Cancer Registry Annual Report were used. Incident cases and deaths coded as C11 according to the 10th revision of the International Classification of Diseases, together with corresponding population data from 2018 to 2022, were extracted. Crude rates, age-standardized rates by the Chinese standard population, age-standardized rates by the world standard population, and cumulative rates from 0 to 74 years were calculated and stratified by sex, residence, and age. Joinpoint regression was used to estimate the average annual percentage change (AAPC) and 95% confidence interval (95%CI) of age-standardized rates by the Chinese standard population.
Results In 2022, 4560 incident cases of nasopharyngeal carcinoma were reported in Guangxi cancer registration areas, with a crude incidence rate of 9.09 per 100000 and a Chinese age-standardized incidence rate of 7.50 per 100000. A total of 2581 deaths were reported, with a crude mortality rate of 5.14 per 100000 and a Chinese age-standardized mortality rate of 3.84 per 100000. The incidence and mortality rates were higher in males than in females, with male-to-female ratios of 2.40 and 3.25 for Chinese age-standardized incidence and mortality rates, respectively. Rural areas had slightly higher Chinese age-standardized incidence and mortality rates than urban areas. Age-specific incidence peaked in the 55-year age group, while mortality peaked in the 70-year age group. From 2018 to 2022, the overall Chinese age-standardized incidence rate decreased significantly, with an AAPC of -5.20% (95%CI: -7.99% to -2.32%, P=0.011). The rates in urban areas, males, and females also decreased significantly, while the rate in rural areas showed a decreasing tendency but was not statistically significant. The overall, urban, and rural Chinese age-standardized mortality rates showed decreasing tendencies but were not statistically significant. The Chinese age-standardized mortality rate in males decreased significantly, with an AAPC of -5.35% (95%CI: -10.28% to -0.14%, P=0.047).
Conclusion Nasopharyngeal carcinoma remains a high-burden cancer in Guangxi, particularly among males, rural residents, and middle-aged and older populations. From 2018 to 2022, the Chinese age-standardized incidence rate showed a significant decline, whereas the Chinese age-standardized mortality rate showed an overall decreasing tendency but with insufficient statistical evidence. Continuous interventions for high-risk populations, early detection and treatment, and standardized prevention and treatment services in rural areas are needed. |
