| County-level cancer registration serves as the foundational support for the national cancer prevention and control system. This study examines the policy documents, implementation plans, and related frameworks for cancer registration system development in Gong''an County and Honghu City, and compares the similarities and differences between the two regions'' cancer registration efforts across multiple dimensions, including developmental trajectories, implementation pathways, and experiential insights. The results show that both counties have achieved the transition from project-based surveillance sites to international inclusion in Cancer Incidence in Five Continents, yet their pathways differ markedly: Gongan County exhibits a pattern of "project-site initiation, 15-year gradual progression, and steady advancement," while Honghu City demonstrates a model of "demonstration-zone driven, curve-overtaking, and rapid compliance." Gongan County and Honghu City represent two successful paradigms for county-level cancer registration work—the former emphasizing "continuous accumulation and steady, step-by-step progress," and the latter highlighting"project-driven efficiency and breakthrough performance." The experience from both counties indicates that government coordination, whole-process quality control, technical support, and long-term sustainability are critical success factors for county-level cancer registration, though the specific pathways can be flexibly chosen based on local conditions. |